Diuretic response was defined as kilograms of weight loss per 40 mg of the loop diuretic furosemide.
The first was to confirm preliminary findings of the PROTECT trial, which found that poor
diuretic response is a serious clinical problem.2 The second was to investigate whether the beneficial effects of serelaxin discovered in the primary analysis were related to improvement of the
diuretic response.
The study also found that serelaxin has a neutral effect on
diuretic response.
Poor
diuretic response was not associated with increased 180 - day cardiovascular mortality (p = 0.546).
The more weight patients lost per mg of furosemide given, the better
their diuretic response.»
Poor
diuretic response is associated with worse in - hospital and post-discharge clinical outcomes, results of the RELAX - AHF trial reveal.
The researchers found that serelaxin had no effect on
diuretic response.
The current study shows that the beneficial effects of serelaxin are not through improvement of
diuretic response.
More insights are needed into the problem of poor
diuretic response so that better therapies can be found to improve the
diuretic response and improve clinical outcomes.»
Not exact matches
The known
diuretic effects of caffeine and alcohol, because of their action in inhibiting the release of arginine vasopressin (20, 21), would influence the
response to ingested drinks that contain caffeine or alcohol.