Tumors are home to
diverse immune cell types, some of which remain much less explored than T cells and could also control cancer progression» says Mikael Pittet, PhD, director of the Cancer Immunology Program in the MGH Center for Systems Biology and senior author of the Science paper.
Not exact matches
This program, resulting in shorter 3 ′ UTRs, is a characteristic of gene expression during
immune cell activation and correlates with proliferation across
diverse cell types and tissues.
They found that, while the grafts of undifferentiated iPS
cells harbored large numbers of T
cells of only a few specificities — indicating a robust
immune response — those found in grafts of the two
types of endothelial
cells were more
diverse, suggesting a more limited response associated with a phenomenon known as self - tolerance.
This effort will combine deep knowledge of immunological lineages, clinical expertise and infrastructure needed to procure and process
diverse samples, genomic and computational expertise to resolve the hundreds of finely differentiated
cell -
types that compose all facets of the
immune system, and the genomic signatures that define them.
NK
cells are a key part of the innate
immune system with the ability to recognize and kill
diverse types of tumor
cells, including ovarian cancer.
The complex networks, interactions, and responses of
immune cells produce
diverse cellular ecosystems composed of multiple
cell types, accompanied by genetic diversity in antigen receptors.