Sentences with phrase «division in human cells»

ER - mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells.

It thus seems quite likely that this new signaling path also links the performance of the cellular power plants and cell division in human cells,» says Meisinger, who now plans to analyze these mechanisms in tumor tissues.

O. M. Pereira - Smith and J. R. Smith, Genetic analysis of indefinite division in human cells: Identification of four complementation groups.

Not exact matches

Although de Lange notes that telomere shortening needs further investigation, she says there's now no doubt that telomeres play a critical role in limiting human cell division and that telomerase can reactivate the process.

To see which are involved in heart - cell division, Giacca's team tested 875 human microRNAs in cultured rodent heart muscle.

The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.

When the scientists inserted human colorectal cancer cells into zebrafish embryos and allowed them to grow for 4 days, the resulting tumors showed three hallmarks of human solid tumors: rapid cell division, formation of blood vessels to supply nutrients, and the ability to spread to other locations in the body.

In humans, basal progenitors can undergo multiple rounds of cell division, thereby substantially increasing neuron number and ultimately the size of the neocortex.

The researchers behind the new study say that the fact that this mechanism is highly similar in human cells and yeast cells suggests that it plays a key role in ensuring proper chromosome distribution following each cell division.

He says that his team will work to achieve all the necessary divisions in mice before trying similar manipulations with human cells.

The study was supported by a Science of Human Appearance Career Development Award from the Dermatology Foundation and by grants from the Medical Research Council of the UK, the Empire State Development's Division of Science, Technology and Innovation (NYSTAR), New York Stem Cell Science (NYSTEM), and the Biotechnology and Biological Sciences Research Council in the UK (BBSRC), as well as earlier support from the Steven and Michele Kirsch Foundation.

Dr Nadeau added «Our results are even more surprising because the cortex gene was previously thought to only be involved in producing egg cells in female insects, and is very similar to a gene that controls cell division in everything from yeast to humans.»

And if small RNAs influence cell division in humans as they do in yeast and Tetrahymena, minor disruptions in the machinery could lead to cancer.

The Mount Sinai study found that harmine drove the sustained division and multiplication of adult human beta cells in culture, a feat that had eluded the field for years.

The human cells seemed to invest much more time in the phase of cell division called metaphase.

Over 2,000 miRNAs are present in human cells, playing various crucial roles in development, cell differentiation, cell division, cell death, and cancer development.

Gottschling noticed that after about 25 cell divisions — the equivalent of middle age in humans — DNA errors in daughter cells started appearing 100 times faster than normal.

«We challenged a current dogma in the field that emphasized PLK1's role in mitosis (cell division) as a primary mechanism for cancer growth,» says Zheng Fu, Ph.D., lead investigator on the study, member of the Cancer Molecular Genetics research program at VCU Massey Cancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of Medicine.

«This study adds to an important body of work that has shown the ubiquity of a circadian clock across species, including humans, and its role in metabolic regulation in cells, organs, and organisms,» said Dr. Michael Sesma, Program Director in the Division of Genetics and Developmental Biology at the of the National Institutes of Health's National Institute of General Medical Sciences, which partially funded the research.

This protein is important to milk production, bone growth, and cell division in all animals, including humans.

In studies of laboratory - grown human tumor cell lines, the drug disrupted tumor cell division and prevented growth of advanced cancer cells.

Where the second type of condensin, which is present in humans and other multicellular organisms, binds during cell division is another future line of inquiry.

In preclinical experiments using human prostate cancer cell lines, Fu's team showed that increased PLK1 expression activated an oncogene known as c - RAF, which has previously been shown to play a role in regulating cell growth and divisioIn preclinical experiments using human prostate cancer cell lines, Fu's team showed that increased PLK1 expression activated an oncogene known as c - RAF, which has previously been shown to play a role in regulating cell growth and divisioin regulating cell growth and division.

One hint came in August, when a team led by biochemist Ramin Shiekhattar at the Wistar Institute in Philadelphia reported that a protein complex responsible for lashing the two copies of each chromosome together just before cell division binds to a repetitive element in the human genome.

The team used ChromEMT to image and measure chromatin in resting human cells and during cell division (mitosis) when DNA is compacted into its most dense form — the 23 pairs of mitotic chromosomes that are the iconic image of the human genome.

«We are learning that these two fundamentally different cells are changing each other dramatically, and this might be relevant for other symbiotic systems, including human and parasitic microbe relationships,» said study co-author Eunsoo Kim, an assistant curator in the Museum's Division of Invertebrate Zoology.

Researchers led by Prof. Torsten Ochsenreiter of the Institute of Cell Biology at the University of Bern have studied the mitochondria, the «power plants» of single - cell trypanosomes, and have now discovered that these behave differently from cell power plants in humans during cell divisCell Biology at the University of Bern have studied the mitochondria, the «power plants» of single - cell trypanosomes, and have now discovered that these behave differently from cell power plants in humans during cell diviscell trypanosomes, and have now discovered that these behave differently from cell power plants in humans during cell diviscell power plants in humans during cell diviscell division.

The area of the trabecular meshwork and its surrounding posterior limbus in the human, however, showed considerable fluorescence indicative of cell division (Figure 6B).

It is also pointed out that donor age (beyond 45 years in the alkaline phosphatase - linked BrdU assays) may also have limited the human wounding response (cell division) in the corneal periphery.

This was expected given the many reports of the tendency of a lack of cell division in unstimulated human tissue [14,30].

Thus, neural derivatives of disease - specific human pluripotent stem cells constitute a relevant biological resource for exploring the impact of adult - onset HD mutations of the HTT gene on the division of neural progenitors, with potential applications in HD drug discovery targeting HTT - dynein - p150Glued complex interactions.

In the unwounded human tissue, no fluorescence in the corneal endothelium was an indication of a lack of cell division (Figure 6AIn the unwounded human tissue, no fluorescence in the corneal endothelium was an indication of a lack of cell division (Figure 6Ain the corneal endothelium was an indication of a lack of cell division (Figure 6A).

It would seem, therefore, that cellular division has at least one significant negative control component in both rabbit and human corneal endothelial cells whose activation may be delayed.

This may indicate a continuous partial negative control of cell division in the human, but not the rabbit.

Such results in humans show a typical lack of propensity toward cell division even after wound stimulation.

«We expect to use this approach to help us better understand how the complexity of the human cortex arises from cells that are spun off through cell division from stem cells in the germinal region of the brain.»

To prevent genetic imbalances after cell division, the cell has to make sure that all 46 duplicated chromosomes (in case of a diploid human cell) are bioriented and ready to be pulled in opposite directions.

Dr. Masayo Yumoto, team leader of Regenerative Medicine Research & Planning Division, Rohto Pharmaceutical Co., Ltd., has been holding a leadership role in the joint research lab at the Institute of Medical Sciences, University of Tokyo, to develop next generation cell culture method using human mesenchymal stem cells.

In addition to a critical role in cell division, it is also clear that survivin has a function in protecting cells from apoptosis and that this pathway is followed in nearly every human tumoIn addition to a critical role in cell division, it is also clear that survivin has a function in protecting cells from apoptosis and that this pathway is followed in nearly every human tumoin cell division, it is also clear that survivin has a function in protecting cells from apoptosis and that this pathway is followed in nearly every human tumoin protecting cells from apoptosis and that this pathway is followed in nearly every human tumoin nearly every human tumor.

We have previously identified hundreds of new cell division genes by RNAi - based screening of the entire human genome and we are now studying — in live cells and with high - throughput — protein function, interactions and networks.

The effect of colonization of cdrA (cell division - related gene)- disrupted Helicobacter pylori to host response in human stomach.

By examining the results of genome - wide association studies (GWAS) in conjunction with experiments on mouse and human red blood cells (RBCs), researchers in the lab of Whitehead Institute Founding Member Harvey Lodish have identified the protein cyclin D3 as regulating the number of cell divisions RBC progenitors undergo, which ultimately affects the resulting size and quantity of RBCs.

She has over 15 years of research experience applying analytical methods to biological problems in the fields of neuroscience, stem cell biology, immunology and genetics through her experience working as a postdoctoral scholar in the division of Human Genetics at the University of Minnesota and as a researcher in the early discovery immunology division of Genentech Inc..

Guido Silvestri, MD, division chief of Microbiology and Immunology at the Yerkes Research Center at Emory, and several of his research colleagues performed the first hematopoietic stem cell transplantation in three rhesus macaques infected with a simian human immunodeficiency virus (SHIV).

However, p53 expression has previously been detected in the cytoplasm of normal human corneal endothelial cells [13], and these cells have a limited potential for cell division.

Since these proteins are known to be involved in the regulation of cell division, this study seeks information about their influence in regulating cell proliferation in the human corneal endothelium.

He observed that normal human cells had a finite lifespan in vitro and could execute only a limited number of cell divisions.

The ghastly bear - dinosaur hybrid with a human voice is a notable highlight, while Lena's particular fascination with cell division is mirrored in the way a thing might become a multitude of similar things.

Included in this bundle: Biodiversity and Human Interaction Biologists Cell Division Cellular Transport Chemistry of Life Ecology Evolution and Natural Selection Genetics Human Body General Terms Human Body Circulatory and Lymphatic Systems Human Body Digestive System Human Body Endocrine System Human Body Excretory System Human Body Integumentary System Human Body Muscular System Human Body Nervous System Human Body Respiratory System Human Body Skeletal System Photosynthesis and Cellular Respiration Plant Structure and Function Scientific Method Taxonomy The Cell Types of Science What is Life

Covering: B1 - Cell Structure and transport B2 - Cell Division B3 - Organisation and the Digestive System B4 - Organising animals and plants B5 - Communicable Diseases B6 - Preventing and Treating Disease B7 - Non-Communicable Diseases B8 - Photosynthesis B9 - Respiration B10 - The Human Nervous System B11 - Hormonal Coordination B12 - Homeostasis in Action (GCSE Biology Only) B13 - Reproduction B14 - Variation and Evolution B15 - Genetics and Evolution B16 - Adaptations, Interdependence and Competition B17 - Organising an Ecosystem B18 - Biodiversity and Ecosystems