A large trial showing that men with newly diagnosed, advanced prostate cancer lived ten months longer, on average, when they received
docetaxel chemotherapy along with standard hormone therapy
Previous results from the trial have already changed clinical practice — data released last year has led to
docetaxel chemotherapy now being part of the standard of care for many men with prostate cancer.
Not exact matches
This time, she was given different
chemotherapy —
docetaxel and gemcitabine — as it was assumed that her cancer had grown resistant to the previous drugs, and, after several weeks, the tumours had shrunk right down.
Sengupta and his colleagues took breast cancer cells that did not have the markings of CSCs and exposed them to
docetaxel, a common
chemotherapy drug.
Researchers randomly selected 135 patients to receive nivolumab, sold under the name Opdivo, and 137 others to receive the
chemotherapy drug
docetaxel.
Maintenance
chemotherapy was left to the discretion of the treating medical oncologists and consisted of pemetrexed,
docetaxel, erlotinib or gemcitabine.
For years,
docetaxel has been the only effective
chemotherapy for men whose cancer was no longer responding to hormone treatments.
Patients were randomised 1:1 to receive therapy with ceritinib or
chemotherapy (pemetrexed or
docetaxel).
Research coordinated by the ECOG - ACRIN Cancer Research Group, supported in part by the National Cancer Institute, and published in the current online version of The New England Journal of Medicine, examined the outcomes of giving the
chemotherapy drug
docetaxel at the start of ADT.
Patients received 3 cycles of
docetaxel at either 80 mg / m2 or 100 mg / m2 and trastuzumab three times a week followed by 3 cycles of
chemotherapy.
The trial actually enrolled 938 patients with recurrent advanced NSCLC; physicians initially chose pemetrexed or
docetaxel for patients, after which patients were randomized to either
chemotherapy alone or in addition to a cetuximab regimen.
The BMS trial, called Checkpoint - 017, randomized 272 patients to receive either nivolumab intravenously every two weeks or the
chemotherapy drug
docetaxel intravenously every three weeks.
Pertuzumab was approved by the FDA in 2012 for first - line treatment of HER2 + metastatic breast cancer in combination with trastuzumab and the
chemotherapy docetaxel (Taxotere).
These include anti-seizure drugs like gabapentin,
chemotherapy drugs like
docetaxel and cisplatin, and medications to treat Parkinson's Disease like Mirapex (pramipexole) and Requip (ropinirole).
In 2014, researchers at the National Cancer Conference made the following statement: «Long term significant scalp alopecia (here lasting for up to 3.5 years following completion of
chemotherapy) may affect 10 - 15 % of patients following
docetaxel for EBC [early breast cancer].