Not exact matches
Findings were presented at the WCLC are based
on the updated results of 12 lung cancer patients enrolled in the clinical trial with pembro and irinotecan or gemcitabine with or without vinorelbine or
docetaxel.
A large trial showing that men with newly diagnosed, advanced prostate cancer lived ten months longer,
on average, when they received
docetaxel chemotherapy along with standard hormone therapy
The tissues were grown
on a 3D gelatin sponge, and two portions of the same tumor were treated with either cabazitaxel or
docetaxel.
Analysis of the tumor genes affected by the two drugs revealed that cabazitaxel had a greater effect
on cellular division and regulation of chromatin — a spool for DNA that helps control which genes are in use and when — whereas
docetaxel has a greater impact
on DNA transcription and repair.
«When we embarked
on this study, early clinical trials and laboratory studies supported the possibility (or hypothesis) that earlier therapy in appropriate patients with
docetaxel, used in combination before hormonal resistance occurred, could have greater benefit, but required proof in a definitive study.
Patient 2 was diagnosed with widespread metastatic prostate cancer in 2013 and progressed
on numerous systemic therapies, including leuprolide, bicalutamide, enzalutamide, abiraterone, and eventually
docetaxel.
The U.S. drug maker released a statement
on Monday saying that its Keynote - 010 study, a randomized Phase two - third trial, showed that patients who were taking two different doses of Keytruda (FDA - approved two mg / kg dose and treatment dose of 10 mg / kg given every three weeks) had longer survival compared to those who took
docetaxel, the drug widely used for non-small cell lung cancer (NSCLC).