The following year, Garofalo appeared in no less
than five films, with a supporting part in the ensemble piece 200 Cigarettes, a starring role as an unconventional action heroine called the Bowler in Mystery Men (which also featured Stiller), and prominent turns in Kevin Smith's eagerly awaited Dogma, Hampton Fancher's psychological
thriller The Minus Man, and the satirical comedy Can't Stop Dancing, in which she acted alongside fellow comedienne Margaret Cho.In 2001, Garofolo took on the role of Catherine Connolly in The Laramie Project, HBO's
docudrama chronicling the aftermath of the death of Matthew Shepard, and filmmaker David Wain's comedy Wet Hot American Summer.