Sentences with phrase «does cellular stress»

But what role does cellular stress play in the production of hemoglobin?

Not exact matches

But until he understands how the cells are stressed in the first place, he won't know much: «We frankly don't have a clue as to how much microwave radiation is needed to cause irreversible damage to cellular proteins.

Using these orthogonal measures of cellular pathway analysis, we confirmed that HPP - 4382, in contrast to bardoxolone, did not induce significant cellular stress at high doses as measured by HSPA6 expression and that the mechanism of HPP - 4382 activity does not appear dependent on NF - B as ICAM1 expression is not induced by HPP - 4382 (data not shown).

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

People that do heavy exercising can lower their glutamine levels causing stress to their body and immune systems.18 For that reason supplementing with glutamine can be an important part of a serious athlete's program or someone challenged with loss of muscle, or just wanting to help maintain optimal immune function while under heavy stress.7 - 23 Glutamine supplements cause a rapid rise in cellular glutamine levels and glutamine stores in muscle.