Researchers sequencing the canine genome have identified around 19,000
dog genes compared to the 25,000 or more genes in the human genome.
Not exact matches
The study's 31 samples of
dog tumors was
compared to 40 normal canine tissues samples as a way of estimating the variance in
gene expression.
By
comparing our genetic make - up to the genomes of mice, chimps and a menagerie of other species (rats, chickens,
dogs, pufferfish, the microscopic worm Caenorhabditis elegans, the fruit fly Drosophila melanogaster and many bacteria), scientists have learned a great deal about how
genes evolve over time, and gained insights into human diseases.
A total of 21,257
genes were identified, a number similar to that of human beings and other mammals, and they have been
compared to those of cats, tigers, cheetahs and
dogs.
In the first study, the researchers have used technologies at the SNP&SEQ Technology Platform at SciLifeLab to
compare genes from healthy
dog individuals with
genes from individuals with breast cancer.
He and colleagues Lawrence Grossman and Derek Wildman
compared approximately 10,000 protein coding
genes culled from the dolphin genome with comparable
genes from 9 other animals: a cow, horse,
dog, mouse, human, elephant, opossum, platypus and chicken.
Some of the mutations were in
genes involved with brain development, which the researchers interpreted as relating to the less aggressive temperaments of
dogs compared to wolves.
Next, they
compared the expression of that
gene in
dogs versus wolves and found on average a 28 fold increase in
dogs.
In collaboration with veterinary neurologists in England, researchers at the Hospital for Sick Children
compared the
genes known to be associated with Lafora to the same
genes in affected
dogs.
The reasons are not completely understood, but it seems the health standards in Europe are far higher and the American
gene pool is more closed with fewer stud
dogs being used as
compared to the many great stud
dogs of Europe.
Researchers have identified genetic mutations that cause similar problems in other breeds of
dogs and they want to
compare those
genes to the DNA in French Bulldogs to see if the same mutation might be responsible for the condition.
He and his colleagues
compared dog and wolf DNA to learn which
genes were important for domestication.
Remillard cites a 2013 study led by Swedish geneticist Erik Axelsson, reported in the journal Nature, in which «he reports that in a domestic
dog's vs. wolf's genome comparison, three
genes responsible for the digestion of dietary starch were expressed 7 -12-fold higher levels in the
dog compared to the wolf.»
In evaluating the hips of
dogs genetically predisposed to dysplasia, certain factors could make the hips in the leg - extended radiographs appear worse,
compared to another
dog with presumably the same
genes for hip joint construction, such as a littermate or a
dog with otherwise near - identical genotype yet reared differently.
We identified a conserved sequence, CCCGCG, within this deletion by
comparing the promoter regions of the
dog, cow and horse Cox - 2
genes.
Because this material appears to be more abundant in affected Swedish vallhund
dogs compared to other forms of PRA with primary photoreceptor death or
compared to the normal aging canine retinas, we suspect that the autofluorescent material is intimately associated with the disease - causing
gene mutation.