Sentences with phrase «dog with the mutation»

Dogs that carry both mutations are at the highest risk of getting sick from the disease, although dogs with a mutation in either gene can develop the disease as well.
Over time, the number of clear dogs available will increase and use of dogs with the mutation can be phased out.
Dogs that carry both mutation are at the highest risk of getting sick from the disease, although dogs with a mutation in either gene can develop the disease as well.
Genetic testing is available to identify dogs with the mutation, allowing veterinarians to prescribe safer medications.
Normal dogs with the mutation should be bred only to clear - tested dogs and preference given to clear - tested offspring to carry on with.
«This detection will help avoid breeding boxer dogs with the mutation,» says Bryan Slinker, DVM, Ph.D., dean of WSU's College of Veterinary Medicine.
Normal kidneys reabsorb the Amino Acid cystine so that only small amounts pass into the urine, while dogs with mutations of both copies of the SLC3A1 gene fail to reabsorb cystine allowing large amounts to pass into the urine, hence the name cystinuria.
Dogs with the mutation who remain healthy will pass the mutation to their offspring, who will also be at risk for cataracts.
To further stir up the muck, many dogs with the mutation never develop cataracts.
There are also groups of related dogs with the mutation that don't have cataracts, but some of those dogs are still young and may develop them later.
X-linked diseases are rarely common, so diligent use of the test combined with removing dogs with the mutation from the breeding pool should effectively eliminate the mutation from a breed.
Due to the high frequency of the mutation in the breed and the variety of drugs to which dogs with the mutation can react, all Aussies, including rescues of unknown parentage and Aussie - mixes should be tested.
However, dog owners should know that the doses of US - produced heartworm preventive agents recommended by manufacturers and approved by the Food and Drug Administration are safe for dogs with the mutation.
Dogs with mutations in the MDR1 gene can exhibit sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications.
A genetic test has recently been developed for cerebellar ataxia, which causes a progressive decline in muscle coordination, first appearing between ages 3 and 5 years; now, by identifying dogs with the mutation, breeders can avoid producing it in their bloodlines.
Breeding of dogs with the mutation could be conducted as described above.
However, not all dogs with the mutation became affected, prompting the hypothesis that additional genes could modify disease risk.
You can keep a dog with this mutation slim, but you have to be a lot more on - the - ball — you have to be more rigorous about portion control, and you have to be more resistant to your dog giving you the big brown eyes.»
They were able to confirm that only one parent needs to carry the mutation to pass it to offspring, and not all dogs with the mutation develop the disease.
The mode of inheritance for most Aussie cataracts is dominant with incomplete penetrance, meaning not every dog with the mutation will develop cataracts though 70 % of those with cataracts have it.
Only one parent needs to carry the mutation to pass it to the offspring, and not all dogs with the mutation develop the disease
Dogs with mutations in both copies of the SLC2A9 gene are predisposed to have elevated levels of uric acid in the urine, hence the name hyperuricosuria.
Not all dogs with mutations in both copies of the SLC2A9 gene will have symptoms of disease, though they will have increased uric acid excretion in the urine.
Those dogs with the mutation should be given ivermectin containing medications with caution and may be more susceptible to loperamide, digoxin, odansetrom and many chemotherapeutic drugs also.
When that information is known we'll have a better idea what percentage of the dogs with the mutation will ultimately develop HC.
It is very possible, given the disparity between the numbers of dogs with the mutation and the frequency of cataracts that HSF4 positive / no cataracts families might be possible, but without further study we can not be sure.
You can hold off breeding and get a few annual eye exams done first, then select mates that don't carry the mutation in hopes of producing clear offspring of good quality to replace the dog with the mutation.
It is a risk factor — not every dog with the mutation gets cataracts.
Genetic analysis revealed that German shepherds with certain mutations in the PKP2 gene had a much higher risk of eczema, suggesting that low levels of the plakophilin - 2 protein break down the skin barrier in dogs with the mutation.
Ideally, dogs with the mutation should be bred to clear - tested mates.
Dogs with the mutation should not be bred extensively.
Dogs with the mutation and at least four years of age (to have some assurance that they won't have cataracts) should be bred only to clear tested dogs and preference should be given to clear tested offspring to carry on with.
The mode of inheritance for most Aussie cataracts is dominant with incomplete penetrance, meaning not every dog with the mutation will develop cataracts.
However, eliminating every dog with the mutation is extremely short - sighted and even dangerous in those breeds where it is common.
Based on the author's correspondence and conversations with Aussie breeders since the release of the test, their one biggest conundrum is the fact that not all dogs with the mutation actually have cataracts.
Normal / Normal littermates of dogs with the mutation, if of equal quality, should be given preference for breeding.
Dogs with the mutation will react to those drugs.
Dogs with the mutation would best be bred to those that are Normal / Normal.
Dogs with this mutation have a transport defect — the drug goes in to their brains, fails to be transported out, and builds up to toxic levels.
In the case of acepromazine, dogs with this mutation will be sensitive to acepromazine and become more sedated than expected.
These breeds can be tested for the mutation and the dangerous drugs avoided in dogs with the mutation.
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