Sentences with phrase «dominant mode of action»

Given these findings, we proposed that the dominant mode of action of the ApoC - III ASO in mice is to remove the inhibitory effect of ApoC - III on the clearance of TRLs through LDLR and LRP1, which act in a redundant manner with respect to TRL clearance (17, 23).

Not exact matches

In line with recent research, Gibson Winter finds that «certain metaphoric networks become dominant in a total society, shaping modes of thought, action, decision and life.»

To investigate the potential involvement of Rac in Mcf1 mode of action we micro-injected Mcf1 into Drosophila embryos expressing either dominant - negative (RacN17) or constitutively active (RacV12) versions of the small GTPase, Rac, in hemocytes.

The location of the missense mutations in a key catalytic domain suggests that they are likely to cause loss of catalytic activity but retention of cyclin K binding, resulting in a dominant negative mode of action.