When the studies of mitochondrial carryover were
done in embryonic stem cells derived from ePNT blastocysts (to allow for more cell divisions during which instability could manifest), some stem cell lines displayed instability and an increase in mitochondrial DNA carryover with time.
The only previous demonstration — by researchers led by Shou - Wei Ding, PhD, a professor of Plant Pathology and Microbiology at UC Riverside and co-corresponding author of the current study — was
done in embryonic stem cells and in newborn mice.
Not exact matches
In the time of all this fighting we've had [over embryonic stem - cell research]-- which did slow down this [adult stem - cell] research — in the last year we've advanced ten years.&raqu
In the time of all this fighting we've had [over
embryonic stem -
cell research]-- which
did slow down this [adult
stem -
cell] research —
in the last year we've advanced ten years.&raqu
in the last year we've advanced ten years.»
• President Obama
did not go half far enough
in lifting the ban against federal funding for
embryonic stem -
cell research.
Example
in point: Opposition to
embryonic stem cell / human cloning research: It isn't anti science to oppose treating nascent human life like a corn crop or manufacturing embryos, anymore than it is anti science than the Animal Welfare Act the proscribes what can and can't be
done in scientific research with some mammals.
Starting
in 2007,
in the same French Institute of Health and Medical Research (INSERM) lab where he
did his Ph.D., Catelain worked to harness the potential of
embryonic stem cells for treating cardiac diseases.
The paper doesn't include any genetic analysis of the final eggs that confirms they are healthy, notes Mitinori Saitou, a
stem cell biologist at Kyoto University
in Japan whose team developed methods to create mouse egg
cells from
embryonic or reprogrammed
stem cells.
The final guidelines on research with human
embryonic stem cells issued on Monday by the National Institutes of Health set out criteria for determining which ES
cell lines can be used
in federally funded experiments and give NIH discretion to approve old lines that don't meet stringent modern ethical requirements.
Lamberth granted a preliminary injunction on this research after hearing a petition from a group of advocates who argued that, contrary to the U.S. government's view, research on
embryonic stem cells does in fact destroy embryos — action that is prohibited by legislation known as the «Dickey - Wicker Amendment» to the bill that funds the Department of Health and Human Services.
«Global levels of DNA methylation
in IPS
cells look amazingly similar to
embryonic stem cells,» Ecker says, «but there are distinct regions that
do not get reprogrammed properly.»
We also need a more detailed comparison between iPS
cells and
embryonic stem cells in terms of what they
do.
Scientists were even more stunned
in July 2002 when researchers led by
stem cell biologist Catherine Verfaillie at the University of Minnesota reported that bone marrow — derived
cells they had injected into young embryos contributed to all three
embryonic layers, just as
embryonic stem cells would
do.
In a response to Friday's decision, NIH spokesperson John Burklow said NIH doesn't set aside fixed amounts of money for studying adult or
embryonic stem cells, but instead makes award decisions based on scientific merit and relevance to NIH's priorities.
Unlike
embryonic stem cells, the use of adult
stem cells in research and therapy is not controversial because the production of adult
stem cells does not require the destruction of an embryo.
It is possible to force human skin
cells to turn back into
embryonic stem cells in the lab, but this doesn't seem to be something we are able to achieve without intervention.
Like
embryonic stem cells, iPSC can be differentiated toward any
cell type
in the body, but they
do not require the use of embryos.
I don't know too many other consortia which can integrate expertise
in embryonic and tissue
stem cell biology, tissue regeneration and repair, bioengineering and nanotechnology, materials science, genomics and bio-informatics.
Although Morrison doesn't study
embryonic stem cells — his area is adult
stem cells, including how they develop into cancer
cells — he pushed for a 2008 ballot proposal
in Michigan that overturned a law restricting hESC research.
In January, HHS ruled that the law
does not apply to
embryonic stem cells because they can not develop naturally into embryos.
Scientists
in Canada and Scotland have developed a virus - free method for generating
embryonic - like
stem cells that
does not involve destroying embryos.
He's engaging
in classic hype that the religious right uses whenever this issue comes up — claiming that we don't really need
embryonic stem cells because adult
stem cells are so wonderful that they can take care of everything.
But of course, posed this way the question
does not distinguish between
stem cells obtained
in different ways (and indeed it is sensible to assume that those who expressed opposition
in response to this question believed they were being asked about
embryonic stem cells, although the survey
does not allow us to know that with confidence).
His recent published work describes the rescued visual function
in animals using retinal pigment epithelial
cells derived from human
embryonic stem cells and a method for deriving
stem cells using a single -
cell approach that
does not harm embryos.
What Collins
does not say, however, is that the new NIH guidelines also allow for federal funds to be used
in studying new human
embryonic stem cell lines that are created (by private entities, of course) beyond the 700 currently
in existence.
Human
embryonic stem cell - derived cardiomyocytes engraft but
do not alter cardiac remodeling after chronic infarction
in rats.
Wicker, no political naïf, brought out the big rhetorical ammo, reminding the senators that it was Jamie Thomson, the University of Wisconsin scientist who first reported isolating the
cells in 1998, who said: «If human
embryonic stem cell research
does not make you at least a bit uncomfortable, you have not thought about it enough.»
Even though different
cell types were used as the initial starting materials, and they were made to produce different sets of proteins, both groups identified and isolated
cells nearly identical to human
embryonic stem cells, and
did so
in the same timeframe.
They included cloning (somatic
cell nuclear transfer, accomplished
in many placental mammals),
stem cell gametogenesis (has been
done in mice), direct engineering of early stage embryos (has been
done in several mammals),
embryonic stem cell editing, and primordial germ
cell (PGC) editing.
Instead of starting with
embryonic stem cells, as Astellas
does, several other research groups are working with retinal progenitor
cells found
in the eye.
JOE PALCA: Well, John, what they
did was they - instead of starting with embryos and using those to derive
embryonic stem cells, they started with skin
cells, or actually precursors to skin
cells called fibroblast, that we all have
in our skin.
The biologist
doing more than anyone else to stir the debate is University of Wisconsin researcher James Thomson, who co-discovered human
embryonic stem cells a decade ago,
in November 1998.
«People are jumping
in very rapidly, much more rapidly than they
did 10 years ago» after the initial discovery of
embryonic stem cells, Thomson said.
And meanwhile, university researchers can and
do work on
embryonic stem cells — just so long as they don't use federal funds (which makes for some complicated partitioning of lab equipment
in many a US university department).
Heaven forfend the U.S. be left behind
in a post about religion and politics: Obama's move to lift the ban of federal funding of
embryonic stem cell research didn't sit well with several U.S. states, which have now passed or are considering legislation to outlaw some forms of the work.