Most Alzheimer's research and drug development are
done in mouse models of the disease.
Not exact matches
In humans, α - synuclein would not necessarily turn out to be equally aggressive —
mouse models of neurodegenerative
diseases do not mimic human
disease very closely — but scientists are taking the possibility seriously.
However, Dr. Kissler's group discovered that reducing levels
of the RGS1 protein
did not slow the progression
of the
disease in mouse models, suggesting that it may not offer much potential for human treatment.
In mouse models of the
disease, tau tangles didn't form after the plaques appeared.
A very large number
of changes have been discovered
in HD
model mice and then subsequently observed
in human HD patients, suggesting the
mice are useful research tools, even if they don't really have Huntington's
disease.