Sentences with phrase «donor allograft»

Moreover, in the same study, the mortality rate associated with this treatment over ten years was 10 %, an extremely low rate following a family donor allograft.

Not exact matches

Using an approach developed at Maisonneuve - Rosemont, consisting of an autograft to reduce tumour mass followed by a family allograft three to four months later to clean the bone marrow of myeloma cells with immune cells from a family donor (immunotherapy), the study resulted in a total cure rate of 41 %, a record level using this strategy.

Such allografts have already been performed: a portion of respective tissue is being recovered from a dead donor and placed under the mucosa of the recipient's stomach.

«Our study results highlight that in a young athletic population, allografts (tissue harvested from a donor) fail more frequently than using autografts (tissue harvested from the patient),» said Craig R. Bottoni, MD, lead author from Tripler Army Medical Center in Honolulu, Hawaii.

The capacity of CD8 − T cells from CD4 KO donors to mediate corneal allograft rejection is puzzling and on the surface, counterintuitive, since these cells are presumably double negative (DN) T cells.

The role of DN T cells in corneal allograft rejection was confirmed in two separate in vitro assays in which CD8 − cells were isolated from CD4 KO donors that had rejected corneal allografts and were found to induce apoptosis of donor - specific corneal cells.

However, in vitro assays using spleen cells from CD4 KO mice that had rejected BALB / c corneal allografts failed to detect CTL activity against donor corneal epithelial or endothelial cells.

By contrast, adoptive transfer of CD8 − spleens cells from similar donors resulted in the rejection of corneal allografts in almost half of the hosts.

Development of DTH responses to donor alloantigens has been correlated with corneal allograft rejection.

We have also generated T - regs (CD4 + / 25high / 127low / --RRB- in vitro from donor AD - MSC and recipient peripheral blood mononuclear cells and these T - regs are infused in thymus of renal allograft recipients after kidney transplantation.

MSC - induced Tregs were donor - specific since adoptive transfer of splenocytes from tolerant mice prevented the rejection of fully MHC - mismatched donor - specific secondary allografts but not of third - party grafts.

Analysis of the sample can determine if a kidney donor (potential live kidney donor or deceased kidney donor) or a patient inherited two APOL1 gene renal - risk variants that contribute to poorer renal allograft survival after transplantation.

Upon receiving deceased donor kidneys from African Americans with two APOL1 renal - risk variants, transplant recipients experience earlier allograft failure.

Freedman, B. I., et al. «Apolipoprotein L1 gene variants in deceased organ donors are associated with renal allograft failure.»

For example, if it is determined that a donor kidney is at greater risk for shortened allograft survival based on presence of two APOL1 renal - risk variants, rapid re-assessment of allocation of the kidney may be advisable.

More importantly, chimeric animals were protected from rejection of donor - type cardiac allografts.

Mixed chimerism was first monitored after 14 days, and animals with mixed chimerism greater than 10 % were transplanted donor type 129SvJ cardiac allografts.

Therefore, chimeric MRL mice were transplanted with donor - type 129SvJ cardiac allografts and left untreated.

CD4 + T cells sorted by immunomagnetic beads from splenocytes of animals tolerant to donor - type cardiac allografts were plated at 106 cells / well.