Goyal RK, Lin Y, Schultz KR, Ferrell RE, Kim Y, Fairfull L, Livote E, Yanik G, Atlas M. Tumor necrosis factor - alpha gene polymorphisms are associated with severity of acute graft - versus - host disease following matched
unrelated donor bone marrow transplantation in children: a Pediatric Blood and Marrow Transplant Consortium study.
For that to be done successfully, a bone marrow donor match has to be found, and then chemotherapy given, before a person with the disease is ready to have
donor bone marrow cells transplanted.
According to the researchers, when a specific type of donor T cell called CD4 + was purposefully depleted soon after infusion
of donor bone marrow, GVHD was prevented, while strong graft - versus - leukemia (GVL) effects were preserved.
It is composed of two elements: treating the patient with antibodies on the day of transplant, followed by
a donor bone marrow infusion several days later.
Donor bone marrow is injected into the patient and the bone marrow stem cells establish themselves in the patient's bones.