The expression patterns of cell class - specific markers in mosaic retinas appeared the same in host and donor derived regions suggesting that
donor cells generated all retinal cell classes in approximately normal ratios (Figures 5K — 5N and S2).
Not exact matches
Dr Leonardo Guasti added: «It represents an entirely new concept for the study of the adrenal gland as the ability to
generate donor - specific and functional adrenal - like
cells will facilitate the next generation of
cell - based treatments for adrenal insufficiency, the modelling of adrenal specific diseases, and the testing of personalised interventions on
cells derived from patients.»
Then they would transfuse
donor bone marrow rich in the highly prized stem
cells that are capable of
generating new, normal blood.
«It is amazing that we can use urine samples to
generate pluripotent stem
cells that are directly related to the
donor.
HSCs can be harvested from a suitable
donor and then transplanted into a patient, where, after establishing themselves in the bone marrow, they can
generate healthy blood
cells.
He points out that the extra eggs also have
donor DNA in their mitochondria — small bodies that
generate power for the
cell.
The procedure does not depend on the
donors having been previously exposed to any of these antigens through vaccination or infection; the researchers were able to
generate anti-HIV antibodies from B
cells isolated from HIV - free patients.
To better discern
cell classes and determine how well
donor cells integrated into the retina we deliberately
generated mosaic eyes.
To ensure that
donor and host tissues could be easily distinguished, we
generated EFTF - expressing
cells from transgenic embryos constitutively expressing a variant of yellow fluorescent protein (Venus YFP)[10].
We have also
generated T - regs (CD4 + / 25high / 127low / --RRB- in vitro from
donor AD - MSC and recipient peripheral blood mononuclear
cells and these T - regs are infused in thymus of renal allograft recipients after kidney transplantation.
Cymerus is a patented stem
cell manufacturing process that avoids the problems often associated with deriving MSCs and primary tissue sources, and has the potential to
generate large - scale, low - cost MSCs based on a single blood donation from one adult
donor.
The technical evaluation of projects may require the provision of additional data such as information on the genetic modification of your mutant mouse line if applicable (e.g. affected gene, MGI ID of the gene, type of mutation, ES -
cell line used, genetic background (e.g. number of backcross generations), safety level, description of DNA modification, vector, remaining non-recipient DNA,
donor organism), mutant phenotype (s), special housing or care requirements, current sanitary status, and intellectual property rights (who
generated the mouse line, owner of the mouse line)