Compared with the toxicity that we see with allogeneic
donor hematopoietic stem cell therapy, these toxicities are relatively manageable with close monitoring and close supportive care.
But for blood cancer patients who receive
donor hematopoietic stem cell transplants as part of their treatment, graft - versus - host disease (GVHD) often hampers their recovery.
Not exact matches
Subsequently, the
hematopoietic system has to be replaced with stem cells from the blood of a healthy
donor.
The only curative treatment is a
hematopoietic (blood - forming) stem cell transplant from a compatible
donor.
Mehta J, Gordon LI, Tallman MS, et al., Does younger
donor age affect the outcome of reduced - intensity allogeneic
hematopoietic stem cell transplantation for hematologic malignancies beneficially?
Urgent evaluation to help identify optimal
hematopoietic stem cell
donor for individuals with a hematologic disorder and a family history that raises concerns
Along the way, we became interested in using cord blood as an alternative
donor source for
hematopoietic reconstitution after myeloablative therapy.
Isolation and characterization of mesenchymal adult bone marrow stem cells (MSC) and
hematopoietic stem cells (HSC) from healthy
donors and patients with leukemia.
Use of a lower dose of rabbit anti — T - lymphocyte globulin (ATLG) was superior to a higher dose in children with hematologic malignancies undergoing allogeneic
hematopoietic stem cell transplantation (HSCT) from an unrelated
donor, according to the results of a study published in Lancet Oncology.
University of Texas M.D. Anderson Cancer Center Tumor - specific alloantigen - anergic
donor - derived T - cell therapy after
hematopoietic stem - cell transplantation
Low - Dose ATLG Prevents GVHD in Pediatric Hematologic Malignancies: A newly published randomized phase III study of pediatric patients showed lower doses of rabbit anti — T - lymphocyte globulin (ATLG) was superior to a higher dose in children with hematologic malignancies undergoing allogeneic
hematopoietic stem cell transplantation from an unrelated
donor.
Shier LR, Schultz KR, Imren S, Regan J, Issekutz A, Sadek I, Gilman A, Panzarella T, Eaves CJ, Couban S. Differential Effects of G - CSF on Marrow and Blood - Derived
Hematopoietic and Immune Cell Populations in Healthy Human
Donors.
The increase in expression of
donor type MHC antigens on the HPC - derived
hematopoietic cells was gradual.
Previously the long - term benefits of
hematopoietic stem - cell transplantation in cerebral adrenoleukodystrophy (ALD) are thought to be mediated by
donor - derived replacement of myeloid derived cells, possibly including microglial cells.
Thus, one can transplant fully allogeneic
hematopoietic stem cells and co-transplant, for example, hearts from the
hematopoietic stem cell
donor to induce lifelong
donor - specific acceptance of the transplant, without deleterious immunosuppression [4].