Mice with SNpc
dopamine cell loss caused by 6 - hydroxydopamine or 1 - methyl -4-phenyl-1,2,3,6-tetrahydropyridine spend significantly longer amounts of time at the top of the pole (Ogawa et al., 1985; Matsuura et al., 1997).
Not exact matches
And because carotid - body
cells make lots of
dopamine, they might be able to make up for the
loss of the normal
dopamine - producing neurons.
It is caused by the
loss of brain
cells (neurons) that produce
dopamine, an essential neurotransmitter that allows neurons to «talk» to each other.
Parkinson's leads to the
loss of brain
cells that make
dopamine, a chemical that helps control body movements.
This is also why levodopa — the chemical building block of
dopamine — is the go - to drug for PD: giving the surviving
dopamine - producing neurons more building blocks allows them to eke out more
dopamine, going a long way toward correcting the subset of PD symptoms that are caused by
loss of
dopamine - producing
cells (particularly in the early stages of the disease).
These symptoms are the result of the
loss of specialized
cells in an area of the brain called the substantia nigra pars compacta (SNc) that specialize in producing the chemical signal - molecule
dopamine and are responsible for turning off excess firing of neurons that control muscles.