Not exact matches
The Food and Drug Administration has long permitted its use, but in recent years concerns about the chemical have grown as studies have indicated low
doses of the substance can disrupt hormone systems in laboratory
animals and possibly increase the risk of
cancer or other serious illness.
Studies in experimental
animals have linked high
doses of food dyes to health problems, among them organ damage,
cancer, birth defects, and allergic reactions.
Scientists have linked low
doses of BPA to obesity, diabetes, thyroid disease, breast
cancer, prostate
cancer and other illnesses in lab tests on
animals.
Although researchers have known that nitrites and nitrates at high
doses can cause
cancer in lab
animals, de la Monte's results suggest that long - term, low -
dose exposure to the compounds may be linked to chronic diseases in humans.
But the dogs had no major side effects from taking low
doses of the drug, a worry because rapamycin impairs immune system function and could make
animals (including people) who take it more vulnerable to infection or
cancer.
Interestingly, while massive quantities of safrole caused liver
cancer in lab
animals, it seems that small
doses may actually play a protective role for humans.
«With regards to the warnings that comfrey can cause
cancer and liver disease, most herbal practitioners point out that those results were from studies that isolated the pyrrolizidine alkaloids and fed or injected them into
animal subjects in
doses far higher than any typical usage of comfrey leaf, and that comfrey leaf has been regularly ingested by thousands of people around the world without reported ill effects.»
Animals starting with the most
cancer initiation (high - aflatoxin
dose) developed substantially less foci when fed the 5 % protein diet.
Large enough
doses of aflatoxin are a liver carcinogen in high
doses (it's actually what T. Colin Campbell used to induce liver
cancer in mice during his China Study crusade to indict
animal protein).
On page 45 of The China Study, Campbell mocks the high
doses of carcinogens used in
animal studies to show that carcinogen exposure, rather than nutritional factors such as protein intake, produce
cancer:
The rats were given humongous liver - destroying
doses of the liver toxin to show that it was not the aflatoxin that caused the
cancer; no, only the rats who got both the aflatoxin and the
animal protein got the
cancer.
When the aflatoxin
dose is more moderate,
animals eating a low - protein diet develop
cancer while their higher - protein counterparts remain in mighty fine health.
High
doses of rapamycin are already used in humans to fight
cancer and prevent organ - transplant rejection, but at low
doses, it has also been shown to slow aging and extend life span in several
animals with few or no side effects.
While earlier studies had linked early - stage
cancers and lower sperm counts in
animals to low BPA
doses, no study had ever linked exposure to female reproductive diseases.Not surprisingly, the plastics industry balked at the findings, labeling the scientists as biased and alarmist; they also rejected the BPA link to reproductive diseases as unfounded and based on uncertain science.
«[
Animal tests] can include skin and eye irritation tests where chemicals are rubbed onto the shaved skin or dripped into the eyes of rabbits; repeated oral force - feeding studies lasting weeks or months to look for signs of general illness or specific health hazards, such as
cancer or birth defects; and even widely condemned «lethal
dose» tests, in which
animals are forced to swallow massive amounts of a test chemical to determine the
dose that causes death.»
In its June 1, 1984 issue, The Washington Post reported the issuance of a massive new report by the White House science office supporting the scientific consensus that «agents found to cause
cancer in
animals should be considered «suspect human carcinogens,»» and that «giving
animals high
doses of an agent is a proper way to test its carcinogenicity.»
Even these three chemical groups (and other food and cosmetic chemicals) are classified as «hazardous» by the EPA and FDA, because in high
doses some can cause
cancer and other problems in
animals.
Tags for this Online Resume: Laboratory
Animals, pharmacology, lab
animal science, PK / PD, in vivo research, Toxicology, necropsy, diabetes, Anti-Oxidants, Inflammation, Obesity, Cancer, Animal Models, Blood Pressure, Animal Dosing, Blood Collection and Proc
animal science, PK / PD, in vivo research, Toxicology, necropsy, diabetes, Anti-Oxidants, Inflammation, Obesity,
Cancer,
Animal Models, Blood Pressure, Animal Dosing, Blood Collection and Proc
Animal Models, Blood Pressure,
Animal Dosing, Blood Collection and Proc
Animal Dosing, Blood Collection and Processing
While the effect of these substances in humans is unclear, high
doses are linked to
cancer in animals, according to the National Cancer Inst
cancer in
animals, according to the National
Cancer Inst
Cancer Institute.