Sentences with phrase «dose cytotoxic»
Heretofore, treatment of patients with primary or light chain - associated (AL) amyloidosis has been directed toward reducing the synthesis of the amyloidogenic precursor protein through conventional or high - dose cytotoxic antiplasma cell chemotherapy.
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Conventional transplant conditioning employs radiation and / or high - dose cytotoxic drugs (also known as alkylators) to destroy the bone marrow and blood and immune cells; it also causes widespread cellular damage throughout the body.
Not exact matches
Thus apart from direct cytotoxic effect, the exposure of cancer cells to therapeutic doses of radiation also enhances the survival and proliferation of a fraction of cells which ultimately leads to radiation resistance and therapeutic inefficacy.
A Non-randomized, Open - label Dose - finding Trial of Combined Cytotoxic and Immune - Stimulatory Strategy for the Treatment of Resectable Primary Malignant Glioma
15d - PGJ2 induced significant G2 / M arrest, and exerted time - and dose - dependent cytotoxic effects against all OS cell lines.
Low - dose chemotherapy, radiation, or targeted therapies given in combination with immune checkpoint blockade may prove to be an effective and efficient way to immunize the body against tumor cells,» says CRI Scientific Advisory Council associate director James P. Allison, Ph.D., who identified the first immune checkpoint blockade with his discovery in 1995 that the cytotoxic T lymphocyte antigen - 4 (CTLA - 4) receptor inhibited T cell responses.
In fact at the doses used, the chemotherapy is not having direct cytotoxic activity, i.e. not directly killing the cancer cells.