Sentences with phrase «dose metronomic»

Chemotherapeutic Dose Scheduling Based on Tumor Growth Rates Provides a Case for Low - Dose Metronomic High - Entropy Therapies, Cancer Research (2017).

The second branch of the combination therapy, the low - dose metronomic chemotherapy, was similarly found to exert its therapeutic effect through a novel, hitherto unrecognized mechanism: The metronomic chemotherapy turned out to not primarily target the tumor cells, but to act on the recruitment of yet another tumor - promoting cell population from the bone marrow.

Tsai and colleagues found that such «low - dose metronomic» regimens did not induce the production of ELR + chemokines by cancer - associated fibroblasts.

«They also suggest that low - dose metronomic chemotherapy or targeting the chemokine signaling mediated by chemo - treated fibroblasts may improve the therapeutic outcome in desmoplastic cancers.»

Not exact matches

Frequent, low - dose chemotherapy regimens avoid this effect and may therefore be more effective at treating certain types of breast and pancreatic cancer, according to the murine study «Metronomic chemotherapy prevents therapy - induced stromal activation and induction of tumor - initiating cells,» which will be published online November 23 in The Journal of Experimental Medicine.

The approach, called a «metronomic dosage regimen,» uses significantly lower doses of chemotherapeutic drugs but at more frequent time intervals.

One example of the new metronomic regimen, in this instance, is use of two drugs already common in ovarian cancer treatment — paclitaxel and rapamycin — but at levels a tenth to a third of the maximum tolerable dose.

This therapeutic effect was enhanced by combining the Angiopoietin - 2 antibody with a so - called metronomic chemotherapy: In this kind of therapy, chemotherapeutic drugs are given continuously at much lower dose as in the classical high - dose chemotherapy.

Metronomic chemotherapy is a low dose at high frequency that lowers toxicity and is aimed at the tumor.

The chemotherapy protocol utilizes the drug lomustine in what is called a metronomic dose.

One of her early interests and publications was the use of metronomic low - dose protocols to help slow down cancer progression in patients that may not tolerate high - dose regimens or in cases where high - dose chemotherapy was not a feasible option.