Sentences with phrase «dose pharmacokinetics»
Comparison of the single dose pharmacokinetics, pharmacodynamics, and safety of two novel oral formulations of dimethandrolone undecanoate (DMAU): a potential oral, male contraceptive.
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«Based on the variability of pharmacokinetic parameters and drug clearance, the two Vancomycin nomograms developed to predict therapeutic Vancomycin concentrations in healthy adults did not accurately estimate dosage regimens in older children regardless of weight or age, and therefore should not be used to aid empiric dosing,» said Dr. Jessica Gillon.
This study was a randomized, double - blind, placebo - controlled trial designed to characterize the safety, tolerability and pharmacokinetics of AVI - 7288 after daily repeat dosing.
«Perhaps giving a person the right dose, at just the right time, of a drug with just the right pharmacokinetic properties so its effect will wear off at the right time would work a lot better than bombarding the brain with benzodiazepines, such as Valium, that knock out the entire brain.»
The Phase 1 study of ISIS - SMNRx is a single - dose, dose - escalation study designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 14 who are medically stable.
An Open - Label, Multicenter Phase I Study to Characterize the Safety, Tolerability, Preliminary Anti-Tumor Activity, Pharmacokinetics and Maximum Tolerated Dose of BAY 1251152 in Patients with Advanced Hematological Malignancies
A Multi-arm, Phase Ib, Open - Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of AZD9291 in Combination with Ascending Doses of Novel Therapeutics in Patients with EGFRm + Advanced NSCLC who have progressed following therapy with an EGFR TKI (TATTON)
The pharmacokinetic properties of J147 after a single dose of 20 mg / kg in mice show brain levels of about 600 nM at 2 h, over 10-fold above its EC50 in some cell culture neuroprotection assays [7], with a brain to blood ratio of approximately 0.5.
In a study published in a recent edition of Nano Letters, the Laboratory's Mike Malfatti, Heather Palko, Ed Kuhn and Ken Turteltaub report on accelerator mass spectrometry measurements used to investigate the relationship between administered dose, pharmacokinetics (PK), and long - term...
The randomized, double - blind, placebo - controlled study will evaluate the safety and tolerability of multiple doses of NPT088, as well as pharmacokinetics, immunogenicity and pharmacodynamic characteristics, as measured by Aβ and tau PET imaging.
In a study published in a recent edition of Nano Letters, the Laboratory's Mike Malfatti, Heather Palko, Ed Kuhn and Ken Turteltaub report on accelerator mass spectrometry measurements used to investigate the relationship between administered dose, pharmacokinetics (PK), and long - term biodistribution of carbon 14 - labeled silica nanopartocles in vivo.
In this study, NPT088 was safe and well - tolerated at multiple dose levels, with a suitable pharmacokinetic profile.
individual would be 1.47 mg / kg, but our pharmacokinetic study indicated that in macaques, a dose of 5 mg / kg is to achieve MIC levels in blood for over 80 % of the treatment duration of 12 hours.
The Phase 1b / 2a study of ISIS - SMNRx is a multiple - dose, dose - escalation study designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 15 who are medically stable.
The ascending - dose, single - blind, placebo controlled, randomized trial will evaluate the safety as well as the pharmacokinetic and pharmacodynamic profile of DG041.
First, the pharmacokinetics and dosing requirements for ketone containing drink preparations were characterised in a population of athletes and healthy controls (n = 45).
Extralabel use in food animals necessitates an extralabel withdrawal interval to be assigned by the attending veterinarian on the basis of information on the species, dose, route and frequency of treatment in conjunction with available scientific pharmacokinetic data.
Pharmacokinetics of tramadol hydrochloride and its metabolite O - Desmethyltramadol following a single, orally administered dose in California sea lions (Zalophus californianus).
Pharmacokinetics of a single subcutaneous dose of sustained release buprenorphine in Northern elephant seals (Mirounga angustirostris).
Pharmacokinetics of a single - dose orally administered ciprofloxacin in California sea lions (Zalophus californianus).
Tags for this Online Resume: Leadership, Medication Management, Pharmacokinetic dosing, pricing, Policy and Procedure, IV compounding