When the condition is not responsive to high - dose vasopressors like norepinephrine and vasopressin, it is associated with high mortality, with more than half of these patients dying within 30 days,» Dr. Khanna said.
In ZUMA - 1, 12 % of the patients had a grade 3 or higher cytokine release syndrome and that is essentially a patient requiring mechanical ventilation or needing treatment with a high - dose vasopressor.
The study enrolled 321 patients — 163 treated with angiotensin II and 158 with placebo — who were experiencing vasodilatory shock and had received high doses of conventional vasopressors.