Sentences with phrase «doses of virus»

Now, a research team has shown that a lab - made molecule that mimics an antibody from our immune system may have more protective power than anything the body produces, keeping four monkeys free of HIV infection despite injection of large doses of the virus.

A small animal study suggests that high doses of the virus, called adeno - associated virus 9, can cause severe liver and neuron damage in young monkeys and pigs.

«Previous studies have shown that antibody preparations that protect against low doses of virus may be ineffective against higher doses,» they warn.

According to a report published today in the journal Nature, a team led by scientists from the National Institutes of Health (NIH) has developed a vaccine that protects monkeys from lethal doses of the virus.

When people are exposed to high doses of this virus, they can succumb as well.

Instead, you would have to start with a huge dose of virus, says flu virologist Earl Brown of the University of Ottawa.

The researchers admit that they don't yet know whether these people actually developed symptoms of an infection and recovered or were exposed to a small dose of the virus which they were able to fight off.

Scientists have created a designer protein that stops the influenza virus from infecting cells in culture and protects mice from getting sick after being exposed to a heavy dose of the virus.

Doubling the time a bird can pass along a big dose of virus could in theory increase the likelihood that a disease will spread.

The monkeys who were swabbed with the high dose of virus encountered nearly 80,000 times the number of Zika particles the researchers counted in the saliva from the infected monkeys.

To further assess the effects of E-cig exposure on virus - induced mortality, mice were infected with a higher dose of virus (103 TCID50).

FIP is much more likely to develop when there cats and kittens are challenged with a large dose of virus.

The severity of clinical signs is also dependent upon the dose of virus and specie of bacteria that infected a specific dog.

The severity of clinical symptoms is also dependent upon the exposure to the virus, i.e. duration and mode of contact with the infected dog and the ingested dose of virus through direct or indirect transmission.

The first step of the project will be to determine an optimal and safe dose of the virus for canine patients.

Not exact matches

GMOs are engineered with bacteria and viruses to produce insecticides to survive heavy doses of herbicides.

These babies need follow up tests and further doses of vaccine against hepatitis B virus at one month, two months and twelve months of age for full protection.

less than or equal to lamivudine Acquired Immune Deficiency Syndrome Antiretroviral therapy, usually means 1 - 2 drugs, used in early studies Antiretroviral zidovudine (also known as ZDV) Breastfeeding Baby Friendly Hospital Initiative Breastfeeding and HIV International Transmission Study Combined antiretroviral therapy Centers for Disease Control and Prevention Deoxyribonucleic Acid Exclusive Breastfeeding Enzyme Linked Immunosorbent Assay Food and Agrigulture Organization Fixed dose combination ART, e.g., lamividine, stavudine, and nevirapine Highly Active Antiretroviral Therapy, 3 or more drugs for more effective treatment used in later studies Human Immunodeficiency virus International Atomic Energy Agency Infant feeding Infant and young child feeding Lopinavir cubic millimetre Mother - to - Child Transmission of HIV Non-governmental organization Nevirapine Polymerase Chain Reaction People Living with HIV Prevention of Mother - to - Child Transmission Replacement Feeding Ritonavir Ribonucleic acid, one of the three major macromolecules (along with DNA and proteins) that are essential for all known forms of life single dose NVP United Nations Agencies Joint United Nations Programme on HIV / AIDS United Nations Population Fund United Nations Commissioner for Refugees United Nations Children's Fund U.S. Agency for International Development World Alliance for Breastfeeding Action United Nations World Food Programme World Health Assembly WHO 2010 Guidelines on HIV and infant feeding World Health Organization Zidovudine (same drug as AZT)

Research published in the October 21 issue of Science Translational Medicine uses a virus to deliver an extra dose of the gene p11 to the adult mouse brain.

Polio is one of those viruses where you only need an incredibly small infectious dose to get infected.

Full - scale production of a vaccine that could prevent any illness at all from the strain would require at least three months after the virus's emergence to begin, but it is hoped that vaccine production could increase until one billion doses were produced by one year after the initial identification of the virus.

Data from in vivo mouse models indicate that delivery of the DMAb sequence for the influenza A-targeted monoclonal antibody protected against lethal doses of two very different, clinically relevant influenza A viruses.

«It was not known whether any of these vaccines could provide protection against the new outbreak West African Makona strain of Ebola Zaire currently circulating in Guinea,» said John Eldridge, Chief Scientific Officer - Vaccines at Profectus Biosciences, Inc. «Our findings show that our candidate vaccines provided complete, single dose protection from a lethal amount of the Makona strain of Ebola virus.»

Unfortunately, this process is fraught with problems: It's slow (the eggs typically need to incubate for about half a year), inefficient (on average, it takes one to two eggs to yield a single dose of vaccine), and unreliable: Not only can the eggs spoil, but they may also produce the virus at varying rates.

While the individual effects of the drugs on virus - specific CTL differ somewhat depending on specific assays, schedules, and doses, treatment with any of the three HDAC inhibitors impaired the ability of CTL to kill HIV - infected immune cells.

Not only were the mice protected from lethal doses of flu virus, but the protection was also in large part due to the absence of familiar antibodies against the head, the researchers found.

Results from two studies in sub-Saharan Africa, simultaneously announced today, show for the first time that daily doses of anti-HIV pills taken by uninfected men and women can prevent heterosexual transmission of the virus.

In August the U.S. government ordered millions of doses of a live virus vaccine.

A 12 - week dose of an investigational three - drug hepatitis C combination cleared the virus in 93 percent of patients with liver cirrhosis who hadn't previously been treated, according to a study in the May 5, 2015, issue of The Journal of the American Medical Association.

«Our work so far suggests that this new vaccine strategy induces a level of virus neutralization about 25 times greater, after a single dose, than one sees in standard vaccines,» Weissman said.

Vaccine - mediated protection of nonhuman primates against low doses of cell - free HIV - 1, HIV - 2, or simian immunodeficiency virus (SIV) has been demonstrated.

The first live - attenuated Zika vaccine still in the development stage completely protected mice against the virus after a single vaccination dose, according to new research from The University of Texas Medical Branch at Galveston and Instituto Evandro Chagas at the Ministry of Health in Brazil.

A tiny dose of the proper, healthy RPE65 gene was inserted into a «gentle» virus known as adeno - associated virus (AAV), and the gene - carrying virus was injected by Maguire into the retina of one of Cannata's eyes.

«A successful vaccine requires a fine balance between efficacy and safety — vaccines made from attenuated live viruses generally offer fast and durable immunity, but sometimes with the trade - off of reduced safety, whereas inactivated and subunit viruses often provide enhanced safety but may require several doses initially and periodic boosters.

Results from three Phase III clinical trials (ION - 1, ION - 2 and ION - 3) evaluating the investigational once - daily fixed - dose combination of the nucleotide analogue polymerase inhibitor sofosbuvir (SOF) 400 mg and the NS5A inhibitor ledipasvir (LDV) 90 mg, with and without ribavirin (RBV), for the treatment of genotype 1 chronic hepatitis C virus (HCV) infection have been presented at the International Liver CongressTM 2014.

Tests in macaque monkeys also showed that a single vaccine dose of only 50 micrograms provided strong protection against exposure to Zika virus five weeks later.

National Institutes of Health (NIH) scientists report that a single dose of an experimental Ebola virus (EBOV) vaccine completely protects cynomolgus macaques against the current EBOV outbreak strain, EBOV - Makona, when given at least seven days before exposure, and partially protects them if given three days prior.

In Europe, which has yet to see sustained transmission in communities, four countries cut deals with GlaxoSmithKline to purchase more than 100 million doses of a vaccine that targets the new H1N1 virus.

Each of the volunteers was then administered an intranasal dose (1 milliliter) of 2009 H1N1 influenza virus; the volunteers were required to stay in the study unit for nine days where they were monitored by medical staff 24 hours daily.

In its first test in humans, reported online October 4 in the New England Journal of Medicine, one vaccine based on DNA from the virus elicited an immune response, with 100 percent of participants developing antibodies after a three - dose regimen.

Researchers have identified the dose of dengue virus in human blood that is required to infect mosquitoes when they bite.

Mice vaccinated with the HIS virus survived after being given lethal doses of the flu, while most mice given saline instead of HIS virus died after exposure.

Mice vaccinated with the newly designed influenza virus, called hyper - interferon - sensitive (HIS) virus, survived exposure to lethal doses of several different influenza A strains.

It has been known since 1960 that early doses of polio vaccine were widely contaminated with simian virus 40, or SV40, which infects macaque monkeys.

In previous human challenge trials with this modified virus, Dr. Whitehead and his coinvestigators established the virus dose that would cause all recipients to develop viremia — the presence of virus in the blood — and most to develop a mild rash.

Lower dosages did not generate responses that met this threshold, thereby establishing the minimum dose of influenza virus needed to produce mild - to - moderate illness.

Led by Bavari and Travis Warren, Ph.D., the USAMRIID team performed a series of studies involving a lethal challenge with Marburg virus in nonhuman primates to determine the efficacious dose and regimen of AVI - 7288, as well as to characterize the drug exposures in animals that produced efficacy.

Two days after infecting groups of guinea pigs with a lethal dose of Lassa virus, the scientists treated the rodents daily for two weeks with either ribavirin, low doses of favipiravir, or high doses of favipiravir.

But the drug combines low doses of two antiretroviral agents normally used to treat infection, and some researchers fear that its use in healthy people could have unacceptable side effects and spark the emergence of resistant viruses.

But the Congolese government, worried that the virus could spread rapidly among Kinshasa's 10 million residents, has decided to stretch the 1.7 million doses it has received by giving people 0.1 milliliters of the vaccine each instead of the standard 0.5 milliliters.