Sentences with phrase «down regulation of gene»

Since SP1 is an activator of transcription [45], the deletion of an SP1 site should result in down regulation of gene expression.

Not exact matches

For example, the study found down - regulation of genes involved in interferon tau, the major signal of pregnancy recognition.

Of these genes, nearly half that were being suppressed were regulated by estrogen receptor alpha (ESR1), and their down - regulation was noted by the 30 minute mark.

Four of these potential target genes were significantly down - regulated in the prefrontal cortex of corticosterone - treated rats, and this down - regulation inversely correlated with miR -124-3p levels.

With respect to the host's transcriptome, alcohol feeding was associated with down - regulation in gene and protein expression of bactericidal c - type lectins Reg3b and Reg3g in the small intestine.

Among the 811 unique genes that were significantly up - or down - regulated expression during the night, 267 were showed up - regulation of their expression and 544 were down - regulated.

Among the 844 unique genes that were significantly up - or down - regulated expression during the day, 437 were showed up - regulation of their expression and 407 were down - regulated.

Shorter patient survival was generally associated with up - regulation of genes involved in mitosis and cell growth, and down - regulation of genes involved in cellular differentiation.

Because DDX3 exhibits tumor suppressor functions, such as a growth - suppressive property and transcriptional activation of the p21waf1 / cip1 promoter, and is inactivated through down - regulation of gene expression or alteration of subcellular localization in tumor cells, all these features together suggest that DDX3 might be a candidate tumor suppressor.

Their gene expression profile revealed striking up - regulation of peroxisome proliferator - activated receptor gamma coactivator 1alpha (an up - regulator of mitochondrial biogenesis not normally expressed in white fat), increased uncoupling proteins - 1 and -2, and down - regulation of lipogenic enzymes.

Down - regulation occurred in both hearing and deaf birds, indicative of «motor - driven» [42] gene regulation.

We selected seven genes of known physiological importance to the implantation to validate the RNA - seq results; five genes were associated with down - regulation of IFNT signaling in clones on gestation d18 (IFN.tau.c1, IFTN2, CXCL9, CXCL10, and IFI47), and two genes were up - regulated in d - 34 chorion from cloned samples (C3 and IL6).

For example, the down - regulation of WNT - related genes (WNT7A and WNT11) identified at d 18 may delay the remodeling of the endometrial glands during the window of implantation (44).

The 50 down - regulated genes with significant (p - value ≤ 0.05) and greater than 2-fold level of down - regulation in IDUA - / - canine arteries, compared to controls.

Microarray identifies extensive down regulation of noncollagen extracellular matrix and profibrotic growth factor genes in chronic isolated mitral regurgitation in the dog.

Disruption of the gene leads to the development of cataracts via multiple pathways, including the down - regulation or loss of post-translational modification of different crystallin proteins [102].

Finally, because we did not measure gene expression, the current results await replication and extension using methods that can clarify whether the observed effects are associated with changes in gene expression that would indicate up or down regulation of TNF.