Sentences with phrase «down regulation of gene expression»

Since SP1 is an activator of transcription [45], the deletion of an SP1 site should result in down regulation of gene expression.

Not exact matches

With respect to the host's transcriptome, alcohol feeding was associated with down - regulation in gene and protein expression of bactericidal c - type lectins Reg3b and Reg3g in the small intestine.

Among the 811 unique genes that were significantly up - or down - regulated expression during the night, 267 were showed up - regulation of their expression and 544 were down - regulated.

Among the 844 unique genes that were significantly up - or down - regulated expression during the day, 437 were showed up - regulation of their expression and 407 were down - regulated.

Because DDX3 exhibits tumor suppressor functions, such as a growth - suppressive property and transcriptional activation of the p21waf1 / cip1 promoter, and is inactivated through down - regulation of gene expression or alteration of subcellular localization in tumor cells, all these features together suggest that DDX3 might be a candidate tumor suppressor.

Their gene expression profile revealed striking up - regulation of peroxisome proliferator - activated receptor gamma coactivator 1alpha (an up - regulator of mitochondrial biogenesis not normally expressed in white fat), increased uncoupling proteins - 1 and -2, and down - regulation of lipogenic enzymes.

Finally, because we did not measure gene expression, the current results await replication and extension using methods that can clarify whether the observed effects are associated with changes in gene expression that would indicate up or down regulation of TNF.