Sentences with phrase «downstream effector»

Sip1 downstream Effector ninein controls neocortical axonal growth, ipsilateral branching, and microtubule growth and stability

In ALK + ALCL, the chimeric protein nucleophosmin - ALK has been shown to activate PI3K and its downstream effector AKT (4).

AKT is a downstream effector of phosphatidylinositol 3 - kinase (PI3K) and a critical mediator of mammalian target of rapamycin (mTOR) activity (6).

In this pathway, dopamine - and an adenosine 3 ′, 5 ′ - monophosphate (cAMP)-- regulated phospho - protein of 32 kilodaltons (DARPP - 32) is phosphorylated or dephosphorylated at three sites, in a pattern predicted to cause a synergistic inhibition of protein phosphatase — 1 and concomitant regulation of its downstream effector proteins glycogen synthesis kinase — 3 (GSK - 3), cAMP response element — binding protein (CREB), and c - Fos.

Partial activation of the yeast pheromone response pathway by beta - adrenergic receptor agonists was achieved in cells coexpressing h beta - AR and a mammalian G protein (Gs) alpha subunit - demonstrating that these components can couple to each other and to downstream effectors when expressed in yeast.

Ubiquitination of K - Ras enhances activation and facilitates binding to select downstream effectors.

Actually, almost all signalling pathways that affect cell growth and proliferation directly regulate rRNA synthesis, their downstream effectors converging at the Pol I transcription machinery.

Rho GTPases and the Downstream Effectors Actin - related Protein 2/3 (Arp2 / 3) Complex and Myosin II Induce Membrane Fusion at Self - contacts.

PKA and actin play critical roles as downstream effectors in MRP4 - mediated regulation of fibroblast migration.

«Inhibition of mTOR, or its downstream effectors, may represent a novel chemopreventive strategy for this type of aggressive HCC,» she said.

We are currently identifying the downstream effectors of this CAMKK2 - AMPK kinase pathway including Tau and some key effectors of autophagy.

Huynh, T.N., Santini, E., and Klann, E. (2014) Requirment of mammaliant target of rapamycin complex 1 downstream effectors in cued fear memory reconsolidation and its persistence.

Both the Galpha - GTP and Gbetagamma dimer are capable of activating downstream effectors.

Not exact matches

Whereas acute CD8 + T cell effector responses are enhanced in DGKζ - deficient mice postinfection with intracellular pathogens, persistent memory formation is impaired, most dramatically when both DGKζ and DGKα, the other isoform of DGK that metabolizes DAG downstream of the TCR in T cells, are deleted (35, 36).

Deletion of DGKζ from T cells results in prolonged TCR signal transduction downstream of DAG, resulting in enhanced activation of Ras, increased effector T cell proliferation, and amplified cytokine production, which leads to increased antitumor activity against s.c. implanted EL4 tumors or murine mesothelioma (12, 16, 17).

Because treatment with rapamycin also led to decreased AKT phosphorylation in ALK + ALCL cells in our in vitro study, it is tempting to speculate that an effector protein downstream of mTOR - raptor may contribute directly or indirectly to AKT activation.

Our present work is aimed at the identification of the interaction partners of the mPAR - 1, its upstream effectors and downstream targets.

Serine / threonine kinase AKT is a downstream kinase of PI3K and a critical PI3K effector [26].

The Pseudomonas syringae type III effector AvrRpt2 functions downstream or independently of SA to promote virulence on Arabidopsis thaliana

We are currently investigating the details of the signaling cascades involved in these phenomena, as well as attempting to identify cytoplasmic binding partners for NG2 which may serve as effector molecules for activation of downstream signaling events.