Sentences with word «doxorubicin»

We have recently completed a study evaluating toceranib in combination with doxorubicin as treatment for cancer in dogs.

: Therapy with MIA - 602 significantly reduced tumor growth and enhanced the efficacy of doxorubicin in both cell lines.

In the new study, Popp exposed breast cancer cells to doxorubicin alone and measured their viability following treatment.

Results: Therapy with MIA - 602 significantly reduced tumor growth and enhanced the efficacy of doxorubicin in both cell lines.

A number of breast cancer treatments are toxic for the heart notably chemotherapy with anthracyclines, such as doxorubicin, or with trastuzumab (Herceptin).

Researchers led by Patricia Donahoe and Xiaolong Wei of Massachusetts General Hospital and Harvard Medical School found that the common chemotherapy agent doxorubicin actually encourages the growth of ovarian cancer stem cells.

Dr Ghigo said: «The inhibitor was able to completely protect the mice from developing heart failure after doxorubicin treatment.»

Control MX - 1 tumors grew by 907 %, while tumors treated with MIA - 602 enlarged by 434.8 % and with doxorubicin by 815 %.

In general, a well - seated IV line is a priority when doxorubicin is administered.

TRINOVA - 2 is evaluating pegylated liposomal doxorubicin in combination with either placebo or trebananib in previously treated patients with ovarian cancer while TRINOVA - 3, also known as ENGOT - Ov2 and Gynecologic Oncology Group — 3001, is studying the use of trebananib in front - line treatment adding it to carboplatin / paclitaxel.

Down - regulation of c - FLIP was even more prominent when rapamycin was combined with 1 μmol / L doxorubicin.

But the aptamers were designed to bind either to an anticancer drug called doxorubicin or an antibiotic called kanamycin.

Upset stomachs, generally short - lived, are not unusual two to five days after doxorubicin use.

Treatment with the combination of MIA - 602 and doxorubicin resulted in an increase in volume of only 76.2 %.

The single - agent Doxorubicin protocol offers a 60 - 80 % response rate.

Similar results were obtained by electrochemical voltammetric in situ detection of DNA oxidative damage caused by the reduced anthracycline doxorubicin, a classical chemotherapeutic which intercalates into DNA [81].

Combination of the GHRH antagonist with doxorubicin increased this inhibition of growth.

The combination of MIA - 602 and doxorubicin reduced the increase in tumor volume to 256 %.

to both protect the heart from doxorubicin and prevent tumour growth.

«Since doxorubicin is one of the cheapest drugs that is effective against many types of cancer but rarely used in colon cancer, the combination therapy could be highly effective in combating colon cancer while drastically lowering risk of cardiotoxic side effects.»

Too large a dose can cause congestive heart failure, among other side effects, while a small dose may be overwhelmed by immune cells, which consider doxorubicin a foreign invader.

A Randomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles of Docetaxel Plus Cyclophosphamide or Four Cycles of Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel) to Chemotherapy Plus Trastuzumab in Women with Node - Positive or High - Risk Node - Negative HER2 - Low Invasive Breast Cancer

Although doxorubicin can be effective at killing tumor cells, its noxious impact can hurt healthy tissues as well.

Studies have found, however, that Doxil doesn't perform significantly better than the original doxorubicin drug at slowing cancer's advance or in prolonging patients» lives.

Barenholz's team put doxorubicin inside 100 - nanometer particles made of lipid (fat) molecules, decorated on the surface with a polymer that attracted water molecules.

The analysis of doxorubicin resistance in human breast cancer cells using antibody microarrays.

Toll - like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice.

The approval was based on a clinical trial comparing brentuximab vedotin plus conmbination chemotherapy (Adriamycin [doxorubicin], vinblastine and dacarbazine, or AVD) vs a chemotherapy - only regimen commonly used to treat cHL (AVD plus bleomycin, also known as ABVD).

Drugs used in chemotherapy, such as ifosfamide and doxorubicin hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.

Karpas 299 and SU - DHL1 cells were treated with LY294002 at a concentration of 0, 10, or 20 μg / μL as described elsewhere (5), rapamycin at a concentration of 0, 10, 20, and 40 μg / μL with or without 1 μg / μL doxorubicin, and AKT - II inhibitor (Calbiochem; ref.

Shining ultraviolet light triggers the release of the remaining doxorubicin, leaving behind only the biodegradable remnants of the nanoparticle.

Li W, Fan JG, Bertino JR: Flavopiridol enhances doxorubicin - induced apoptosis in human sarcoma cells lacking Rb protein.

Tumor volume of mice given doxorubicin increased by 201.6 % (± 7.1 %) and was also significantly (P < 0.001) reduced compared to controls.

Therapy of doxorubicin resistant MX - 1 tumors with MIA - 602 or combination led to significant (P < 0.05) reduction in MDR1 and NANOG gene expression relative to controls.

The combination of MIA - 602 and doxorubicin decreased growth of MX - 1 tumors by 72 %.

Treatment with the combination of MIA - 602 and doxorubicin led to an increase in final tumor volume of only 256.0 % (± 10.3 %).

The agent, approved in 1995, has the benefit of a reduced side effect profile compared to its traditional counterpart — delivery of free doxorubicin.

The first nanoparticle - based treatment to be FDA approved for cancer was Doxil — a formulation of the chemotherapy agent doxorubicin delivered via the nanoparticle material liposome.

While patients treated longer term with doxorubicin often develop cardiomyopathy — the weakening of the heart muscle — patients treated with Doxil do not typically develop the same side effect.

One small, oft - cited study of breast cancer patients taking doxorubicin (Adriamycin) suggests that scalp cooling can make a significant difference.

The scans are primarily used to monitor heart transplant patients and cancer patients undergoing chemotherapy regimens that are potentially harmful to the heart (namely doxorubicin).