Despite
dozens of regions
in the
genome associated with CAD, most of the genetic components of heart disease are not fully understood, suggesting that more
genes are out there to be found.
Recently, prospects for xenotransplantation brightened when Harvard geneticist George Church demonstrated the removal of
dozens of endogenous retroviruses from the pig
genome,
in a tour de force of the CRISPR / Cas9
gene editing technique.
Genetic studies using samples along the distribution range of both subspecies and based on a few
dozen nuclear markers have revealed loci of relatively high divergence (0.3 — 1.2 %) between subspecies embedded
in a
genome otherwise characterized by low levels of differentiation and high levels of bidirectional
gene flow [21], [24]--[26], likely facilitated by high effective population sizes, high dispersal, and a relatively short generation time [21], [24]--[26].