Dr. Brewer confirmed, speaking clearly, carefully choosing his words, «It extends all the back to 1848,» with the case of Phineas Gage who famously survived being impaled through the head with an iron rod that injured his frontal lobes but suffered
dramatic changes in his personality (you can check out his skull and the iron rod at Harvard's Countway library of medicine where it is on display).
However, her
personality changes dramatically after a terrifying night
in her dorm when she experiences seizures and finds herself
in the grip of a suffocating force (all shown
in dramatic fashion).