Sentences with phrase «drive large decreases»

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

But the team found the opposite: the passenger pigeon's strong social structure favored beneficial mutations for living at high densities, driving selection throughout the species and decreasing genetic diversity in large sections of the genome where recombination seldom occurs.

The Spec V features a silent chain drive, liquid filled engine mounts, and a compact balancer system for the purpose of decreasing vibration frequently present in large four cylinder engines.

Declines in usage for both auto - features are driven primarily by decreases in the micro and large plan segments.

In states that enact strong legal protections, the result is a large net decrease in payday loan usage; borrowers are not driven to seek payday loans online or from other sources.

But animal advocates agree that the decrease in euthanasia has been dramatic, driven mostly by successful spay - neuter programs and, more recently, by savvy adoption campaigns, greater efforts to reunite lost pets with owners and the proliferation of advocacy groups both small and large that have swept in to help municipal shelters, often poorly funded and sluggish.

[1] CO2 absorbs IR, is the main GHG, human emissions are increasing its concentration in the atmosphere, raising temperatures globally; the second GHG, water vapor, exists in equilibrium with water / ice, would precipitate out if not for the CO2, so acts as a feedback; since the oceans cover so much of the planet, water is a large positive feedback; melting snow and ice as the atmosphere warms decreases albedo, another positive feedback, biased toward the poles, which gives larger polar warming than the global average; decreasing the temperature gradient from the equator to the poles is reducing the driving forces for the jetstream; the jetstream's meanders are increasing in amplitude and slowing, just like the lower Missippi River where its driving gradient decreases; the larger slower meanders increase the amplitude and duration of blocking highs, increasing drought and extreme temperatures — and 30,000 + Europeans and 5,000 plus Russians die, and the US corn crop, Russian wheat crop, and Aussie wildland fire protection fails — or extreme rainfall floods the US, France, Pakistan, Thailand (driving up prices for disk drives — hows that for unexpected adverse impacts from AGW?)

This is a result of a weaker wind - driven ocean circulation, when a large decrease in heat transported to the deep ocean allows the surface ocean to warm quickly, and this in turn raises global surface temperatures.

The retreat has been most noticeable at high elevations, driven in large part by warming temperatures contributing directly to melting and indirectly to more precipitation falling as rain rather than snow, in turn increasing the rate at which the glaciers move and increasing the size of glacial lakes, both decreasing ice cover.

The fact is, some drivers may not even see a decrease; drivers with a good driving record will see larger rewards and those with worse, will not.

The fact is, some people may not even see a decrease; drivers with a good driving record will see larger rewards and those with worse, will not.

Because there are multiple people like Randy who have a relatively large position in the Bitcoin market, when these people decrease their position in Bitcoin to an amount that they are comfortable owning during a bear period (and that number may be zero) their collective ask offers are capable of creating a sell - wall that drives down the price of Bitcoin.

«The modest decrease in October's Home Purchase Sentiment Index is driven in large part by decreases in favorable views of the current home - buying and home - selling climates, a shift we expect at this time of year moving out of the summer home - buying season,» says Doug Duncan, chief economist and senior vice president at Fannie Mae.

This decrease was driven in large part by an improvement in house price levels.

According to the CoreLogic report, the decrease in negative equity is driven in large part by an improvement in home prices.