Not exact matches
These chemicals, called cytokines,
drive the inflammation in the brain, attracting more
immune cells, and causing the debilitating disease marked
by loss of neurological function.
«This remodeling process of the
cell proteome
by autophagy is an important
immune - suppressive survival mechanism for Ras -
driven cancers, and inhibiting autophagy can provide a means to target these aggressive cancers,» notes White, who is also a distinguished professor of molecular biology and biochemistry at Rutgers School of Arts and Sciences.
In their latest study, researchers at La Jolla Institute for Allergy and Immunology identified a key signal that
drives the commitment of immature Tfh
cells into fully functional Tfh
cells and thus
driving the step -
by - step process that results in a precisely tailored and effective
immune response.
Research led
by scientists at the Gladstone Institutes has identified the precise chain of molecular events in the human body that
drives the death of most of the
immune system's CD4 T
cells as an HIV infection leads to AIDS.
Even though STAT3 activity
drives the expansion of MDSCs and is involved in
immune responses mediated
by the
cells, they found that high levels of STAT3 activity actually prevent the differentiation of MDSCs to macrophages.
Shortly after infection, HIV levels skyrocket, but then the
immune system and other antiviral factors produced
by cells drive down the amount of virus in the blood — the so - called viral load — and establish a «set point.»
With respect to biological applications, the group is focusing on how cellular heterogeneity and
cell - to -
cell communication
drive ensemble - level decision - making in the
immune system, with an emphasis on «two - body» interaction (e.g., host
cell - virus interactions, innate
immune control of adaptive immunity, tumor infiltration
by immune cells).
Anna Huttenlocher, University of Wisconsin, USA Neutrophils in the Tumor Microenvironment Neutrophils, Wounds, and Cancer Progression Stefan Kaufmann, Max Planck Institute, Germany Pathology and
immune reactivity: understanding multidimensionality in pulmonary tuberculosis Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic
cells Kathryn Moore, New York University, USA MicroRNA -33-dependent regulation of macrophage metabolism directs
immune cell polarization in atherosclerosis Lalita Ramakrishnan, University of Cambridge, UK Myeloid Growth Factors Promote Resistance to Mycobacterial Infection
by Curtailing Granuloma Necrosis through Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia
drive synaptic and cognitive impairment in disease?
IGF prevents frailty
by increasing skeletal muscle mass (sarcopenia), sex
drive (infertility), brain thymus (immunosenescence, centenarians maintain a strong
immune system), skeletal bone mineralization and marrow stem
cell formation (osteoporosis and
immune system
by bone marrow
immune cells working in tandem with thymus and lymphs nodes), I understand that diabetes, an accelerated aging phenotype, is insulin IGF and blood glucose
driven.
• Disease -
driving pathways that involve the human
immune system are often targeted
by antibodies, and Organ - Chips recreate complex interactions of different human
cell types and aspects of the human
immune system, overcoming limitations of animal models which do not reflect all human
immune cells.