Sentences with phrase «driven by inflammation»

To do this, they used a mouse model of liver cancer driven by inflammation.

The good news is that they have identified strategies that stop this damage, which is driven by inflammation.

The researchers also show how diversity and adaptation in BabA adhesins» pH - sensitivity is driven by inflammation and disease progression.

But we think that rapamycin may also be beneficial for those tumors that are driven by inflammation,» she said.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Pitta's who are governed by the elements of fire and water will benefit from the cooling qualities of coconut cream that will help to pacify a tendency towards heat imbalance driven problems including fever, inflammation and skin troubles like eczema.

The research team also found that the action of a gene, ATG16L1, kept TNF alpha - driven inflammation from triggering the self - destruction of too many Paneth cells, by an explosive process called necroptosis.

As a first step, his team is testing whether it's possible to stop or slow tau - driven neuron loss and inflammation by lowering ApoE in the early life of laboratory rodents.

The skin inflammation of eczema is known to be driven by «type 2» immune responses.

Aging is also associated with inflammation driven by microglia in specific regions of the brain, but it is unclear whether diet or lifestyle can influence this process.

These chemicals, called cytokines, drive the inflammation in the brain, attracting more immune cells, and causing the debilitating disease marked by loss of neurological function.

Another is that blood markers of inflammation, perhaps driven by a mix of genetics and external risk factors, may both boost risk and predict that gray matter loss.

An enzyme that plays an active role in inflammation could be a natural way to suppress tumors and ulcers in the colon that are found in colitis associated cancer (CAC), a type of colorectal cancer that is driven by chronic inflammation, according to a new study.

The team notes that the results of their study suggest that current means of testing and approving food additives may not be adequate to prevent use of chemicals that promote diseases driven by low - grade inflammation and / or which will cause disease primarily in susceptible hosts.

An evaluation of «IL4I1 augments CNS remyelination and axonal protection by modulating T - cell driven inflammation», recently published in Brain.

Instead, the real cause of obesity - associated joint overload may be inflammation — body - wide inflammation driven by the microbes that...

The research team showed switching off a gene called NF - κB1 caused spontaneous development of stomach cancers, driven by chronic inflammation.

RIPK2 might thus play an important role in cell migration (Wu et al., 2012), metastasis (Wu et al., 2012), and offer alternate novel therapeutics for abnormal inflammation driven by the NOD2 / RIPK2 pathway.

We have demonstrated the importance of c - ABL in driving inflammation injury in our acute DSS model in the publication by Gordon et al. (2013).

The paper, Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis, http://cancerres.aacrjournals.org/content/76/8/2115, April 2016 found that colorectal cancers associated with B. fragilis could be suppressed, not just by eradicating the microorganism, BUT ALSO BY REDUCING INFLAMMATIOby eradicating the microorganism, BUT ALSO BY REDUCING INFLAMMATIOBY REDUCING INFLAMMATION.

With psoriatic arthritis there is both a digestive and immune component that need to be addressed and the pain and immobility is driven primarily by your inability to down - regulate inflammation.

Undigested proteins such as gluten and other toxins leak across the gut and into the bloodstream where the immune system responds by driving more inflammation and therefore, autoimmunity.

Excess sugars are converted to lipids by the liver, driving up triglycerides, which can increase inflammation and atherosclerosis.

A study by the American Heart Association found that the same inflammation that drives atherosclerosis also increases your chances for developing cancer.