Sentences with phrase «driven cycle over»

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Partly because most inflation problems were demand driven over the course of the cycle, there was a continuing belief that if the cycle could be smoothed, inflation would be contained, and both fiscal or monetary policy were available instruments in addressing the cycle.

While valuations drive long - term returns, the primary driver of market returns over shorter portions of the market cycle is the attitude of investors toward risk, as indicated by the uniformity or divergence of market internals.

Historically - reliable valuation measures are remarkably useful in projecting long - term and full - cycle market outcomes, but the behavior of the market over shorter segments of the market cycle is driven by the psychological inclination of investors toward speculation or risk - aversion.

Instead, the behavior of the market over shorter segments of the cycle is driven not only by valuations but also by the preference of investors toward risk - seeking or risk - aversion.

Valuations are the primary driver of long - term returns, and the risk - preferences of investors — as conveyed by the uniformity or divergence of market action across a broad range of individual stocks, industries, sectors and security types (including credit)-- drive returns over shorter portions of the market cycle.

While long - term market returns are driven almost exclusively by valuations, investment returns over shorter segments of the market cycle are highly dependent on investor psychology, particularly the inclination of investors toward speculation or risk - aversion.

Put simply, valuation drives long - term returns, and investor risk - preferences drive returns over shorter portions of the market cycle.

The central message of our discipline is that valuations are enormously informative about prospects for long - term and full - cycle returns, but that outcomes over shorter segments of the market cycle are driven by changes in the psychological preferences of investors toward speculation or risk - aversion.

Then they're repainted, clear - coated and packed off to pro shops and driving ranges, where the cycle starts all over again.

Plus, as may happen with other sound machines or apps on your phone, you won't be driven to the brink of insanity by the Dohm, by waiting for the loop to «click over» into the next cycle, or by waiting for that sixth whale tone or bird call, or be totally creeped out at 2 a.m. by the sound of a beating heart (oh yes, that's a sound machine option, too).

«Mayor Boris Johnson must improve air quality by prioritising funding for measures that will get Londoners driving less and walking, cycling and using public transport more - and scrap traffic generating schemes like new road crossings over the river Thames.»

Over the next six years, scientists noticed that the plumes varied in brightness (a proxy for how much material is gushing from the moon) on a daily cycle, probably driven by Saturn's different positions in Enceladus» sky.

Cycles that drive changes in the ocean's chemistry and organisms take place over hours, days, seasons, years and even decades — timescales NEPTUNE can track.

The driving force behind the events in the radiation belts is the sun, which is in the midst of solar max — the peak of solar activity, which rises and falls over a roughly 11 - year cycle.

Irregular or absent menstrual cycles, hair loss on the scalp and excessive hair growth all over, acne and oily skin, belly fat, depression or mood swings, infertility, high or low sex drive, high blood pressure, high lipids, insulin resistance leading to sugar and carb cravings, skin tags or darkened skin around neck / elbows, irritable bowel, joint pain, sleep issues, obstructive sleep apnea

Once Upon a Time in Anatolia (Bir zamanlar Anadolu «da)(d. Nuri Bilge Ceylan) Elder statesman Bela Tarr's The Turin Horse, in perhaps capturing the dead - horse - beater that anecdotally drove Nietzsche mad, proceeds to beat a dead horse over the course of increasingly deadening, though never less ferocious, cycles of hardscrabble, meaningless existence.

The new 991 Turbo averages 29 mpg on the European driving cycle, which seems very impressive, since this represents a 16 percent improvement over the previous 997 Turbo.

Looking at the numbers; Saving 10 - percent on fuel for a vehicle that gets only 8 mpg over a yearly driving cycle of 40,000 miles is almost eight times more valuable than increasing the fuel economy of a vehicle getting 30 mpg that is driven only 20,000 miles per year.

On a full charge, the battery is claimed to provide the e-tron quattro concept with a range of over 311 miles based on the criteria used in the New European Driving Cycle (NEDC) test procedure.

The company says that over the NEDC standardized European driving cycle, its plug - in diesel hybrid will emit less than 50 grams of carbon dioxide per kilometer.

Oh, to be sure, the lucky few that can afford BMW's top - of - the - line sports car will laud its picayune emissions (just 49 grams of carbon dioxide emitted every kilometre according to the New European Driving Cycle) as motivations to park the i8 in their driveway, but the real reason they'll fork over $ 145,000 + is what happens when they push the throttle.

The real test of the Equinox will be how it drives and feels over a full test cycle.

Automatic transmission specialist Antonov reports that its comparative studies of an electric vehicle equipped with its multi-speed transmission over eight different drive cycles suggest that the transmission delivers typically 10 % better cycle efficiency than a single - speed solution.

Automatic transmission specialist Antonov reports that its comparative studies of an electric vehicle equipped with its multi-speed transmission over eight different drive cycles suggest that the transmission... Read more →

With Kia development teams targeting a pure electric range of over 60 kilometres (combined, New European Driving Cycle) before its 2.0 - litre GDI (gasoline direct injection) engine kicks in, the new model could emit just 34 g / km CO2 (combined, NEDC), ensuring low running costs and maximum practicality for private and fleet buyers.

Unless you're a serious off - roader, avoid the four - wheel - drive 178bhp 2.0 diesel as it returns just over 55mpg on the combined cycle and emits 134g / km of CO2.

Over my mixed driving cycle, which included a bit of sporty driving, I averaged just 25 mpg.

In the European combined driving cycle, the gasoline direct injection system improves fuel consumption by 10 % over the counterpart V6 gasoline engine with port injection and fully variable valve timing.

The project aims to deliver full hybrid equivalent fuel economy and performance with less than 70 g / km CO2 emissions as measured over the European Drive Cycle, but at a significantly lower cost.

We were able to get about 37 miles per gallon out of our Civic LX - S over a combined cycle of highway and city driving.

We averaged 21.7 mpg over a combined cycle of about 130 miles of city / highway driving and about 100 miles of pretty severe mountain - road flogging.

We managed 19.8 mpg over our combined testing cycle that heavily favored city driving, but as you'll soon learn that's because having fun in the Beetle requires a heavy right foot.

Fuel consumption in combined - cycle testing favours this Equinox variant (6.9 L / 100 km) by nearly three litres over the 2.4 - litre Captiva auto (front - wheel drive) and 1.3 L / 100 km ahead of the Captiva 5, even with a 2.2 - litre diesel / auto combination.

Over the same tightening cycle that ended in 2006, the impact on the 10 - Year U.S. Treasury Bond yield was 60 bps higher, driving the 1 - Year / 10 - Year slope to flatten by 265 bps (see Exhibit 1).

The lessons we have learned from the previous cycles are that over the short - term valuations tend to be driven by supply / demand and fear / greed.

This gradual removal of CO2 from the atmosphere reduces the overall greenhouse effect and thus slowly draws the entire planet into an ice age, driving further ice sheet expansion over tens of thousands of years (a complete ice age cycle is around 100,000 years)

[Response: To pre-empt some mutual incomprehension, note that industrial CO2 rises are certainly an anthropgenic forcing and not a response (see here and here), but clearly CO2 changes over glacial - interglacial cycles is both a response (to Milankovitch - driven changes) and a forcing (since the additional radiative forcing from CO2 is about a third of that needed to keep the ice ages as cold as they are — see here).

Thoman says the weather service has pretty good data collected over the past 65 years on the so - called Pacific Decadal Oscillation, or PDO, cycle that drives El Ninos and La Ninas.

Researchers have also known about and documented periodic shifts over cycles of 21,000 years, 41,000 years and 100,000 years, all of them also driven by astronomical change.

Ocean cycles in large part drive the global temperature over year and decadal scales.

And yes, the Lunar driving cycles are not effective all of the time, since they slowly drift in and out of phase over the centuries.

As discussed in the article on natural cycles of ocean «acidification», and illustrated in the graph below by Martinez - Boti, over the past 15,000 years proxy data (thick lines) has determined surface pH has rarely been in equilibrium with expectations (green line) based on models driven by atmospheric CO2.

In the 1970s, scientists showed that that Milankovitch cycles have driven repeated warming and cooling of the planet, and thus the waxing and waning of ice ages over the last few million years.

The amount of gasoline consumed over a normal daily driving cycle is dramatically reduced with the introduction of up to 9kWh of electricity from the grid.

Stephen Wilde's hypothesis is a possible mechanism for the notch - delay theory, in which the TSI drives surface temperatures after a delay of one sunspot cycle (~ 11 years) and which potentially explains most of the temperature variations over the last few hundred years.

If all that CO2 does is to marginally raise global temperature over the period of a natural solar driven warming and cooling cycle then there is nothing to fear because the mitigating effect in cool periods will outweigh any discomfort from the aggravating effect at and around the peak of the warm periods.

If safety and self - driving technology off - cycle credits are a proposed solution to the current impasse over 2022 - 2025 vehicle standards between federal regulators, the auto industry, and California, then we all need to be clear about the costs.

Even higher in the atmosphere (above 30,000 feet or 9,000 meters) high - pressure air over the storm's center also removes heat from the rising air, further driving the air cycle and the hurricane's growth.

An active commute also reduces greenhouse gas emissions and therefore prevents climate change - If 10 % of citizens in C40's North American Cities switch from driving to cycling that would save over 1.6 million tonnes of CO2e per year, equivalent to 180 million gallons of gasoline consumed.