Sentences with phrase «driver mutation prevalence»
Its characteristically low mutational burden, high copy number and structural variants, and unique driver mutation prevalence are important in helping us understand the natural history of the disease and its response to various therapies.
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«In addition to having a higher prevalence of triple - negative breast cancers than Caucasian women — something that has been documented in previous studies — we found that African American women with breast cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,» says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the study.