Sentences with phrase «driver mutations as»

Temporal specimens collected and tested during the course of treatment identify the loss or elimination of driver mutations as well as emergence or re-emergence of new clones and new potential therapeutic targets.

Invivoscribe also offers comprehensive MyAML ®, MyHeme ®, MyMRD ®, and custom gene panels, that when used in combination with Invivoscribe's proprietary MyInformatics ® Software can identify and track primary driver mutations as well as the subclonal architecture and emergence of new driver mutations in patients with hematologic disease.

Invivoscribe's clinical laboratories also offer comprehensive MyAML ®, MyHeme ®, MyMRD ®, and custom gene panels, that when used in combination with Invivoscribe's proprietary MyInformatics ® Software can identify and track primary driver mutations as well as the subclonal architecture and emergence of new driver mutations in patients with hematologic disease.

Not exact matches

Researchers developed models to examine the influence of driver mutations — mutations that promote cancer development — on the initiation and development of gliomas, and how tumor genomic profiles evolve as the cancer progresses.

«Once identified, we further tested their role as cancer drivers, for example by looking at molecules with and without mutations and comparing their structure and function,» he adds.

Researchers from the University of North Carolina, Chapel Hill, found that the rates of spontaneous mutation in DNA — a key driver of evolution — rise very steeply as temperatures increase.

As the first step in a next generation knowledge system for cancer, the GDC enables and accelerates efforts to identify both high - and low - frequency cancer driver mutations, assists in revealing the genetic determinants of response to therapy, and informs the composition of clinical trial cohorts.

A major challenge for assessing driver mutations, such as epidermal growth factor receptor (EGFR) mutations, in advanced disease is the scarcity of suitable biopsy tissue for molecular testing.

The generation of new mutations is a key driver of evolution but also of susceptibility to rare diseases Fathers pass on four times as many new mutations as mothers do, but the maternal contribution is particularly strong in 10 % of the genome that is prone to...

Panels run at the time of diagnosis identify both clinically - actionable driver mutations associated with the primary tumor, as well as the subclonal architecture that may be present.

# 36: The subtitle of Spencer's book suggests, that there is some «intelligence» that drives the climate and fools the scientists — in the same way as evolution is driven by some intelligent designer that fools the scientist with fossiles indicating that random mutations, change of environment and selection are drivers of evolution.