Sentences with phrase «driving tumor cell growth»

According to Sabatini, who is also a Howard Hughes Medical Institute investigator and professor of biology at MIT, this pathway is hyperactive in an estimated 50 - 80 % of cancers, driving tumor cell growth and proliferation.

Not exact matches

«Tumor cells produce larger quantities of H2O2 and use oxidative signals at higher levels than normal cells in order to drive their own growth,» says Mirko Sobotta, first author of the publication.

Myc no longer was able to drive tumor growth, cancer cells committed suicide, and the treated mice survived longer.

Scientists now know that what matters most in determining the behavior of a particular cancer (and its response to specific therapy) are the molecular pathways that drive malignant cell growth instead of where the tumor begins in the body.

If the stem cells lose Numb, however, p53 levels plunge and the cells proliferate uncontrollably, leading to the emergence of cancer stem cells that drive the growth of breast tumors.

The stem cell model says that tumor growth is more hierarchical, mainly driven by a subset of cells that can make new copies of themselves and give rise to the other cell types the tumor contains.

About half of melanoma patients harbor an identical tumor - specific mutation in the BRAF gene, which encodes a protein kinase that helps drive cell growth.

The study showed that the tumor cells only contain one cilium and have disrupted Sonic Hedgehog signaling, which drives tumor - cell growth.

As described in a study posted online May 21 by Science magazine, the strategy uses tumor cells» own protein - chopping machinery to break down and dispose of proteins that drive cancer growth.

The inability of cells to differentiate makes them vulnerable to genetic mistakes that drive cancer, since more «stemness» means a tendency toward rapid, abnormal growth seen in tumors.

Anna Huttenlocher, University of Wisconsin, USA Neutrophils in the Tumor Microenvironment Neutrophils, Wounds, and Cancer Progression Stefan Kaufmann, Max Planck Institute, Germany Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells Kathryn Moore, New York University, USA MicroRNA -33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis Lalita Ramakrishnan, University of Cambridge, UK Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia drive synaptic and cognitive impairment in disease?

Over the last 3 years, the partnership between the Salk Institute and Ipsen has delivered significant scientific advances in the cancer field such as the development of biological models mimicking human cancerous processes as well as identification of specific cells driving tumor growth.

Runaway cell proliferation is driven by accelerators, or oncogenes, that are stuck on go — in collusion with broken brakes, or tumor suppressors, that can't control a tumor's pedal - to - the - metal growth.

Many studies in tumor models have forcibly provided 4 - 1BB signals, injecting either agonist antibodies to 4 - 1BB, or transfecting 4 - 1BBL into the tumor cells, also highlighting the stimulatory capability of 4 - 1BB in driving suppression of tumor growth largely through augmenting CTL and NK responses.

The model will describe cellular pathways that contribute to tumor formation and explain in detail how the genetic disposition of an individual can activate expression of genes that drive uncontrolled cell growth and lead to cancer.

The goal of genomic tumor testing is to identify genomic changes in the cancer cells that are driving cancer growth for the...