Researchers report a surprising mechanism through which an important new candidate
drug against leukemia exerts its therapeutic effect...
Not exact matches
Already one epigenetic
drug, 5 - azacytidine, has been approved by the Food and Drug Administration for use against myelodysplastic syndrome, also known as preleukemia or smoldering leuke
drug, 5 - azacytidine, has been approved by the Food and
Drug Administration for use against myelodysplastic syndrome, also known as preleukemia or smoldering leuke
Drug Administration for use
against myelodysplastic syndrome, also known as preleukemia or smoldering
leukemia.
So if researchers think that an individual
drug for, say, chronic myeloid
leukemia might work
against a different kind of tumor because the two illnesses share similar biological underpinnings, they have to conduct a whole new clinical trial and go through the approval process all over again for the second condition.
Wapner's narrative follows developments from the recognition of a chromosomal abnormality in cancer cells to the production of a targeted
drug against what had been a lethal
leukemia.
Co-senior study investigator and cancer biologist Iannis Aifantis, PhD, says the study offers the first evidence that «
drugs targeting and disrupting
leukemia cells» microenvironment — or what goes on around them — could prove effective
against the disease.»
A class of therapeutic
drugs known as protein kinase inhibitors has in the past decade become a powerful weapon in the fight
against various life - threatening diseases, including certain types of
leukemia, lung cancer, kidney cancer and squamous cell cancer of the head and neck.
The
drug imatinib mesylate (Gleevec) is shown to be effective
against chronic myelogenous
leukemia (CML).
Researchers at the University of Michigan Comprehensive Cancer Center have developed a new
drug candidate that shows potential in laboratory studies
against a rare type of acute
leukemia.
This new therapy works well
against B - cell acute lymphomblastic
leukemia, a cancer of the blood system, which has led the U.S. Food and
Drug Administration to expedite approval of the first CAR - T treatment for children and young adults.
Researchers at SciLifeLab has together with research physicians at Karolinska University Hospital and scientists at Heidelberg University identified a key player determining response to cytarabine — the most important
drug against acute myelogenous
leukemia.
The
drug Gleevec, which has been touted in some circles as a miraculous silver bullet
against some forms of
leukemia, can still fail in patients who develop mutations that cause the
drug to lose...