The origins of our best
drug against malaria have long been a mystery.
Intelligent design became a scientific reality this year with the report that researchers had custom - made a lifesaving microbe — one that helps make a much - needed
drug against malaria.
A group of new
drugs against malaria does more than just kill parasites; it may also restore the efficacy of a generation of older drugs called quinolines to which parasites around the world have become resistant.
The research of the Department of Parasitology is focused on developing vaccines and
drugs against malaria and TB, using non-human primate models.
Not exact matches
Novartis's global head of
drug development and chief medical officer, Vas Narasimhan, has a piece up on Fortune exploring the strides that have been made in the fight
against malaria, including the development of an experimental Novartis treatment called KAF156.
This means that in the global fight
against malaria, we need to do everything we can to slow the rise of
drug - resistant forms of the disease.
A commonly used anti-parasite
drug could be the next weapon in the fight
against malaria.
Preliminary results of the study were presented at a World Health Organization (WHO) evidence review group meeting, while UNITAID has issued a call for further research into the use of endectocide class
drugs, of which ivermectin is currently the only one registered for human use, as new vector control tools in the fight
against malaria and other mosquito borne disease.
Strains of
drug - resistant tuberculosis are on the rise in Eastern Europe and Central Asia, and
malaria has roared back as one
drug after another has become ineffective
against the parasite.
The World Health Organization (WHO) released a plan today to deal with a threat that could undermine the recent success in
malaria control: the emerging resistance
against artemisinin
drugs, which are the cornerstone of
malaria treatment worldwide.
«Potent parasite - killing mechanism of anti-malarial
drug uncovered: New understanding of how artemisinin works could facilitate development of new
drugs and therapeutic strategies
against malaria.»
A team of researchers from the National University of Singapore (NUS) has uncovered the mystery behind the potent parasite - killing effect of artemisinin, a
drug that is considered to be the last line of defence
against malaria.
We've already moved away from using quinine to treat cases as the
malaria parasite has become more resistant to it, but if further
drug resistance were to develop
against our most valuable
malaria drug, artemisinin, we would be facing a grave situation.
A study by researchers from the National University of Singapore has uncovered the mystery behind the potent parasite - killing effect of artemisinin, a
drug that is considered to be the last line of defense
against malaria.
Tulane University researchers have developed a new
drug that is effective
against non-severe cases of
malaria, according to results from an FDA - supervised clinical trial published in the latest issue of The Lancet Infectious Diseases.
«The ability of MMV048 to block all life cycle stages of the
malaria parasite, offer protection
against infection as well as potentially block transmission of the parasite from person to person suggests that this compound could contribute to the eradication of
malaria, a disease that claims the lives of several hundred thousand people every year,» said Professor Chibale, Founder and Director of H3D, founding Director of the South African Medical Research Council (SAMRC)
Drug Discovery Research Unit at UCT, and senior author of the paper.
Medical researchers have developed a new treatment
against drug - resistant strains of the Plasmodium falciparum parasite that causes
malaria.
A new paper published in the journal Science Translational Medicine describes the discovery and biological profiling of an exciting new anti-malarial clinical
drug candidate, MMV390048, effective
against resistant strains of the
malaria parasite, and across the entire parasite lifecycle, with the potential to cure and protect in a single dose.
For instance, one great recent advance in the fight
against malaria is a
drug called artemisinin.
A subsidy program intended to drive down the cost of lifesaving
malaria drugs called artemisinin - based combination therapies — now considered the most effective treatment
against the parasitic disease — was unveiled today in Norway.
Artemisinins are a family of
drugs that currently form the frontline treatment
against Plasmodium falciparum
malaria.
Cutler says semi-synthetic artemisinin should help ensure access to the crucial
drug and would be a significant victory
against malaria.
«We've been trying to treat it with the
drugs used
against malaria, but it would be better to use those
drugs that are used on fungi.
The trick, reported in the August issue of Nature Structural Biology, may lead to
drugs against a host of infectious diseases, from
malaria to AIDS.
«As
drug resistance is a major problem for
malaria control and eradication, it is critical that that we continue to develop new antimalarials that act
against previously unexploited targets in the parasite to keep priming the
drug pipeline.»
The studies support the concept of using natural exposure in combination with
malaria - fighting
drugs to help people build up protection
against disease, says
malaria vaccine researcher Robert Sauerwein of the Radboud University Nijmegen Medical Center in the Netherlands.
(The
drugs are not yet commonly used
against malaria.)
This release comes at a time when the latest wave of antimalarial
drug resistance, including the frontline
drug, artemisinin, is threatening gains made
against malaria.
Chloroquine has become ineffective
against malaria, and resistance to the other frontline
drugs is emerging,» says senior author of the study Professor Dominic Kwiatkowski, of the Wellcome Trust Sanger Institute and Oxford University.
Conducting seminal intervention trials
against malaria that have fed directly into national and international policy which has contributed to the prevention of millions of deaths; these include trials of impregnated bed nets, the prevention of
malaria in pregnant women, interventions to improve community based treatment and interventions to increase access to safe effective
drugs.
An ingredient commonly found in toothpaste could be employed as an anti-malarial
drug against strains of
malaria parasite that have grown resistant to one...
Regardless of artemisinin's effectiveness
against malaria and other diseases caused by parasites and despite its anti-tumour potential, its usage faces a problem: the low content produced by the plant and the high cost of its chemical synthesis result in a scarce and expensive
drug.
Safety and efficacy concerns with currently used
drugs accentuate the need for new chemotherapeutic options
against severe
malaria.
Current topics include vaccine efficacy testing and immune correlates of TB, AMA1 as a
malaria blood stage vaccine candidate in clinical development and development of new
drugs active
against malaria hypnozoites.
WEDNESDAY, Feb. 21, 2018 (HealthDay News)-- A
malaria drug that's also shown effectiveness
against rheumatoid arthritis pain has failed to help people with the more common form of arthritis, new research shows.