Sentences with phrase «drug against this protein»

Not exact matches

One is PEG - asparaginase, a version of E. coli asparaginase that has been chemically modified to extend the drug's effect by reducing excretion by the kidneys and formation of antibodies against the protein.

To learn how Mycobacterium tuberculosis mounts a defense against a drug, Baliga is first looking within the bacterium, identifying the genes, proteins and other molecules that interact as the microbe infects a host.

Chemogenomics is a new concept where drug design and screening is conducted at the genome level for selective drug discovery effort against one target among a large family of related proteins / receptors.

In contrast to viral proteins, the host targets are less prone to mutations and thus drugs targeting them could be more effective against viruses, which mutate easily.

The extreme diversity of the PfEMP1 genes and proteins may be a problem, however, because a drug that disables one protein might not work so well against another.

That knowledge and the cloaking proteins themselves might now be turned against the toxin - the deadliest known to humankind - to deliver vaccines or drugs that could prevent or treat the disease.

New supercomputer simulations have revealed the role of transport proteins called efflux pumps in creating drug - resistance in bacteria, research that could lead to improving the drugs» effectiveness against life - threatening diseases and restoring the efficacy of defunct antibiotics.

Paradoxically, some drugs that disable Hsp90 have shown promise against cancer, by stopping the cancer from building proteins it needs to survive.

This will give way to the development of a drug to be used in gene therapy against neurodegenerative diseases based on small molecules which enhance the expression of the gene and / or the use of fragments of the Klotho protein itself.

«Identifying a cancer driver is crucial for cancer treatment because it allows the use of targeted therapies, which have less side - effects than conventional chemotherapy drugs, against a particular protein,» said Kurokawa.

They also showed that drugs against a type of breast tumor called HER2 positive breast cancer — such as the dual ERBB2 / EGFR inhibitor lapatinib — potentially could benefit more patients than currently receive them, if analysis of the tumor proteins is taken into consideration.

To find drugs that act specifically against a protein without also binding to others that are similar — and so causing side effects — it is important to understand this binding site in detail.

An entire class of proteins called transcription factors, which regulate the activity of certain genes by interacting with specific sequences of DNA, has largely been ignored by the pharmaceutical industry because it's difficult to design and screen drugs against them.

Since these proteins serve as «master regulators» for controlling whole gene programs, drugs against these targets could have broader effects than traditional ones that block single enzymes.»

A class of therapeutic drugs known as protein kinase inhibitors has in the past decade become a powerful weapon in the fight against various life - threatening diseases, including certain types of leukemia, lung cancer, kidney cancer and squamous cell cancer of the head and neck.

«Agents that block the proteins — CDK4 / 6 inhibitors — have received Food and Drug administration approval for some patients with metastatic breast cancer, but they've also shown promise against others types of tumors in clinical trials.

This approach, in which structure and activity is not linked to a specific protein target, can cause other difficulties and slow the progress of discovery, not least because of the difficulty of assessing relevant toxicity against host mechanisms and the inability to use structure - guided drug - design to drive Medicinal Chemistry progress.

The researchers will use their findings to focus on developing drugs in the future that work against BCL - 2 proteins for potential treatments.

With this knowledge, computer models can measure millions of potential drug molecules against the tau protein, giving immediate clues to suggest which should be tested further.

Therefore, we investigated the currently used drugs and existing compounds with activity against cancer - related proteins and their first neighbours in the SignaLink network to point out and select potential new anti-cancer drugs (Fig. 5a).

The combination of grape extract and physical activity offers more protection than physical activity alone 06.03.2018 Grape Seed Extract during menopause: fewer hot flushes, more muscle and better sleep 12.08.2015 Poo smells less with Grape Seed Extract supplement 08.08.2015 Slimming supplement containing ECGC, resveratrol and Grape Seed Extract shown to work in human study 12.01.2014 Grape Seed Extract speeds up damaged muscle tissue recovery 15.09.2013 Grape Seed Extract keeps big eaters» weight down 11.12.2012 Grape Seed Extract helps prevent swollen legs 06.08.2012 Grape Seed Extract inhibits «genetically inevitable» prostate cancer 14.07.2012 Resveratrol and Grape Seed Extract protect against skin cancer 02.03.2012 Red grape juice is a smart drug 18.11.2011 Gallic acid is the anti-cancer agent in Grape Seed Extract 12.11.2011 Grape Seed Extract protects against prostate cancer 11.11.2011 Grape Seed Extract protects against skin cancer 29.10.2011 Anti-cancer supplements like GSE need plant - based proteins to be effective 21.09.2011 Arginine with grape extract enhances condition condition 25.06.2010 Grape Seed Extract inhibits aromatase & glucocorticoid receptor 05.08.2009

Campbell writes on page 51 of The China Study that he first investigated the effect of dietary casein on drug - metabolizing enzymes in order to test the hypothesis that low - protein diets might protect against cancer:

Unfortunately for some cats, the drug can not be used long term because the immune system recognizes the drug as «foreign» and will make antibodies (immune proteins) against it.

You'll see similar ones about «curing cancer» when they've identified a new protein that MIGHT be a drug target, against which drugs MIGHT be developed, which MIGHT or MIGHT NOT be better than current drugs and which will only come to market in 15 years.