In Bar Harbor, MDI Biological Laboratory and its spinout company, Novo Biosciences, said they have identified a potential
drug candidate derived from a shark that may restore heart muscle function after a heart attack.
Up the road in Bar Harbor, MDI Biological Laboratory and its spinout company, Novo Biosciences, said they have identified a potential
drug candidate derived from a shark that may restore heart muscle function after a heart attack.
«Although more than 30
drug candidates derived from fragment - based methods have entered the clinic, Wyss's work shows this approach can be effective even on a particularly difficult target,» comments Daniel Erlanson, the symposium organizer and cofounder of Carmot Therapeutics, a biotech company that focuses on FBLD.
Not exact matches
Currently, Deng's laboratory is conducting additional preclinical studies using the human -
derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other
candidate drugs.
Attrition of novel
drug candidates due to cardiovascular liabilities (including proarrhythmic risk due to delayed ventricular repolarization and Torsades - de-Pointes arrhythmia) remains a hurdle for
drug discovery efforts, a hurdle which may be mitigated by the use of human induced pluripotent stem - cell
derived (hiPSC)- cardiomyocytes.
The aim of this collaboration is to identify innovative
drug candidates and biomarkers for immunotherapy of various types of cancer, starting from patient tumor
derived material.
• Personalized
drug safety can be addressed with patient -
derived cells in Organ - Chips, enabling a patient - specific approach for assessing the safety and efficacy of new
candidates while taking into account patient variability and the unique biology of individual patients.