Sentences with phrase «drug candidates with»

In the past year and a half, laboratory scientists have discovered three drug candidates with the potential to activate regeneration in humans.

In only a few years, our unique approach has identified drug candidates with the potential to treat major diseases, demonstrating that regeneration could be as simple as taking a pill.

The findings of this study suggest a new way to find more effective drug candidates with optimal kinetic and thermodynamic properties.

Not exact matches

In December, Tehrani signed a deal with GlaxoSmithKline that will allow the pharmaceutical giant to test at least four of its drug candidates on a Zymeworks - designed platform, which combines a computer simulation with a way of engineering protein molecules and allows products to be refined before they move to expensive clinical trials.

Topics included: early reporting on inaccuracies in the articles of The New York Times's Judith Miller that built support for the invasion of Iraq; the media campaign to destroy UN chief Kofi Annan and undermine confidence in multilateral solutions; revelations by George Bush's biographer that as far back as 1999 then - presidential candidate Bush already spoke of wanting to invade Iraq; the real reason Bush was grounded during his National Guard days — as recounted by the widow of the pilot who replaced him; an article published throughout the world that highlighted the West's lack of resolve to seriously pursue the genocidal fugitive Bosnian Serb leader Radovan Karadzic, responsible for the largest number of European civilian deaths since World War II; several investigations of allegations by former members concerning the practices of Scientology; corruption in the leadership of the nation's largest police union; a well - connected humanitarian relief organization operating as a cover for unauthorized US covert intervention abroad; detailed evidence that a powerful congressional critic of Bill Clinton and Al Gore for financial irregularities and personal improprieties had his own track record of far more serious transgressions; a look at the practices and values of top Democratic operative and the clients they represent when out of power in Washington; the murky international interests that fueled both George W. Bush's and Hillary Clinton's presidential campaigns; the efficacy of various proposed solutions to the failed war on drugs; the poor - quality televised news program for teens (with lots of advertising) that has quietly seeped into many of America's public schools; an early exploration of deceptive practices by the credit card industry; a study of ecosystem destruction in Irian Jaya, one of the world's last substantial rain forests.

«We look forward to working with the SiteOne team as they advance these drug candidates to clinical trials.»

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SDrug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the Sdrug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

The pipeline is deep with another drug that works similar to Alexion ALXN and a fourth drug candidate similar to Bristol Meyer's Yervoy.

I've owned it for the past three years with a cost average of $ 4.64 - it's the future of cancer treatment in my opinion, with brain cancer patients living 7 plus years on its lead drug and impressive results in its second drug candidate for triple negative breast cancer.

The drug candidate is intended for the treatment of subjects with neuronal ceroid lipofuscinosis, aka Batten Disease, a fatal lysosomal storage disease that primarily affects the nervous system in children.

Rick Perry and Michele Bachmann, two presidential candidates who sparred over the issue of Texas vaccinations, may be floundering in the polls, but the topic of Merck's controversial Gardasil is heating up — with an Austrian physician who studied the drug saying it is not only dangerous, but useless in reducing cervical cancer, the stated reason it was administered to young girls at the behest of Gov. Perry.

A first - time candidate, Eastman said she was inspired to run for Congress by her mother's battle with cancer and the extremely costly prescription drugs that she struggled to afford.

Speaking directly to potential voters, Assemblywoman Nicole Malliotakis, the Republican NYC mayoral candidate, sat down with the Staten Island Advance for a 30 - minute Facebook Live interview last night, answering questions from viewers on transportation, housing, drug addiction, education and more.

Along with this approach, we must demand amnesty for the millions of people damaged by this misguided war on drugs so they can be part of a healthy and sustainable society,» said Theresa Portelli, the State Comptroller candidate from Albany.

New York (CNN)- A self - described «ex-madam» who claims she supplied fellow city comptroller candidate Eliot Spitzer with escorts several years ago is facing charges of illegally distributing prescription drugs, authorities said.

Over 60 Reps, two U.S. Senators and every Republican presidential candidate wants Holder's resignation; Congressman Ron Paul among those who also wants Holder tried in court BY DYLAN SKRILOFF In 2009 and 2010 ATF agents, operating under the authority of the U.S. Department of Justice, funneled weaponry through straw buyers to Mexican drug cartels, with -LSB-...]

With the absence of any candidate of color in the AG's race, Schneiderman has been trying to position himself as the clear choice for Latino and black voters, stressing in particular his efforts on behalf of Rockefeller Drug Law reform and sponsorship of a controversial measure that will count prisoners at their last address for the purposes of legislative redistricting and not whever they're incarcerated.

A GOP candidate running against Sen. Kirsten GillibrandKirsten Elizabeth GillibrandOvernight Health Care — Sponsored by PCMA — Trump hits federally funded clinics with new abortion restrictions Dem senators ask drug companies to list prices in ads Gillibrand to publish children's book about suffragists MORE on Sunday sharply criticized the New York Democrat.

We are indebted to my colleague, Nancy Kuntz, MD, and co-author laboratories of Drs. Jasbir Singh and Mike Kiledjian along with Repligen and Families of Spinal Muscular Atrophy (FSMA), who initiated the development of this drug candidate.

Researchers from the UK and Denmark have developed a new method to predict the physical stability of drug candidates, which could help with the development of new and more effective medicines for patients.

Drug candidates currently in late stage clinical trials comprise of growth factors, which are traditional protein - based biological drugs associated with high costs, and some trials have been prematurely terminated.

The three remaining drug candidates that target amyloid - β are currently being tested in people with Alzheimer's, as well as in individuals who have a high risk of developing the disease but who have not yet developed symptoms.

The drug candidate, called mavoglurant, had shown promise in mice with a genetic condition similar to fragile X. The...

The drug candidate, called mavoglurant, had shown promise in mice with a genetic condition similar to fragile X...

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

NMP shares certain mechanistic similarities with other promising drug candidates for myeloma that were discovered in more traditional ways.

In 2008, Ernst and Young ranked Denmark first out of 15 European countries in pipeline growth, with a 23 percent increase from 2006 to 2007 in the number of drug candidates in development.

Even with promising drug candidates, there are often studies that show negative effects, for instance if the dose was too low or the timing of the drug's administration wasn't ideal.

However, CiRA researchers from Professor Junya Tochuchda's lab instead looked at molecules related with inflammation, finding Activin - A as a candidate drug target.

Exploiting the same pre-clinical model used for their studies, the researchers are testing the efficacy of this kind of drug candidates against cancer stem cells, and the possibility of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective of their possible application for the treatment of human breast cancer.

An affordable hepatitis C combination treatment including the new drug candidate ravidasvir has been shown to be safe and effective, with extremely high cure rates for patients, including hard - to - treat cases, according to interim results from the Phase II / III STORM - C - 1 trial presented by the non-profit research and development organisation Drugs for Neglected Diseases initiative (DNDi) at the International Liver Conference in Paris.

«These findings could allow the pharma companies to open up large libraries of potent drug candidates earlier discarded due to solubility problems and try them again together with Upsalite,» says Maria Strømme, Professor at the Division of Nanotechnology and Functional Materials at Uppsala University.

«On the other hand the US Food and Drug Administration has taken the more conservative approach which recognises that SQUIRE was designed for all - comers without prior selection, and this subgroup analysis is insufficient evidence to conclude that patients with EGFR negative tumours are not candidates.»

Conversely, patients with high platelet counts, prone to strokes and heart attacks, might be candidates for estrogen - blocking drugs, she says.

A new paper published in the journal Science Translational Medicine describes the discovery and biological profiling of an exciting new anti-malarial clinical drug candidate, MMV390048, effective against resistant strains of the malaria parasite, and across the entire parasite lifecycle, with the potential to cure and protect in a single dose.

Efforts aimed at finding better drug regimens would therefore greatly benefit from a mouse model with an intrinsic marker that can indicate different stages of pancreatic tumor formation leading to cancer and reflect the effects exerted by novel drug candidates.

When they treated mice modeling HER2 - positive breast cancer with a drug candidate called MSI - 1436 (also called trodusquemine), Tonks and colleagues not only inhibited signaling by PTP1B, but also signaling by HER2 proteins.

The other study — Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma — published March 30, shows how drugs targeting PI3K and MAPK could represent promising candidates for glioblastoma therapy.

«This remarkable team of scientists combined NCATS» expertise in drug screening and development with Mt. Sinai's expertise in Ebola virology to rapidly identified candidate treatments for Ebola infection.»

I read, with fascination, your article on venoms as drug candidates (5 May, p 34).

Geschwind says the «extremely promising results» of the study make the encapsulated drug a good candidate for clinical trials, particularly for patients with pancreatic ductal adenocarcinoma.

Harris cited other examples of concern — a review of 100 studies in the field of psychology in which the findings in only about a third of the studies were reproducible; an effort by scientists at Bayer, another large drug company, that managed to reproduce the findings of only one - quarter of the studies under review; a just - published review of 25 historical candidate genes for schizophrenia which found no evidence that the candidate genes are more associated with the disease than other genes.

Candidates were much more likely to admit to having had mental health issues, used illicit drugs, or committed a crime in a session with the chatbot than they did in a written questionnaire (Computers in Human Behaviour, doi.org/ttp).

Triple - negative cancers are so called because they do not express receptors for the hormones estrogen and progesterone, nor for HER2 (human epidermal growth factor 2), and hence patients with these cancers are not candidates for treatment with modern hormonal therapies or the highly effective HER2 - targeted drug Herceptin (trastuzumab).

The new blood test will initially be used to identify those people with mild cognitive impairment who are likely to get Alzheimer's disease and so might be good candidates for clinical trials to find drugs that halt disease progression.

Afferent Pharmaceuticals today announced publication of results from a Phase 2 clinical trial demonstrating that the company's novel drug candidate, AF - 219, reduced daytime cough frequency by 75 % compared to placebo in patients with treatment - refractory chronic cough.

Those with cancer pain that is not caused by damaged nerves may not be candidates for the drug, Villarreal said.

To narrow down the number of chemical compounds that could be potential drug candidates, scientists utilize computer models that can predict how a particular chemical compound might interact with a biological target of interest — for example, a key protein that might be involved with a disease process.

Conveniently, this cooler temperature acts as a corrector helping more proteins with the Delta F508 mutation to reach the surface, where they encounter the candidate doorman drug.

To search for a doorman drug, Negulescu's team followed almost the identical strategy, but they incubated cells with candidate drugs overnight at a much cooler 80.6 degrees.