«
Drug combinations against Borrelia burgdorferi persisters in vitro: Eradication achieved by using daptomycin, cefoperazone and doxycycline.»
«The end game is to take the guesswork out of chemotherapy, with a clinical test that will assess dozens of drugs and
drug combinations against tumor samples from each patient.»
The researchers tested
the drug combinations against four different human cervical cancer cell lines.
Not exact matches
Called PaMZ, the pill is a
combination of the standard TB
drug pyrazinamide with the antibiotic moxifloxacin — not previously used
against TB — and PA - 824, a
drug whose potential
against TB was reported by New Scientist in 2001.
Just as chemotherapy often requires several
drugs to combat resistance in cancerous cells, successful antimicrobial therapy
against some pathogens requires a
combination of
drugs.
Over the past few years, researchers have seen resistance
against artemisinin derivatives — which are combined with other
drugs in so - called artemisinin - based
combination therapies — emerge in Cambodia, in an area along the border with Thailand.
Exploiting the same pre-clinical model used for their studies, the researchers are testing the efficacy of this kind of
drug candidates
against cancer stem cells, and the possibility of identifying
combination regimens with standard chemotherapies with minimized toxic effects, with the perspective of their possible application for the treatment of human breast cancer.
«As soon as somebody said, OK, this
drug does better than a placebo, then it would be the standard that you test the next
drug against or a
combination of
drugs against.
A subsidy program intended to drive down the cost of lifesaving malaria
drugs called artemisinin - based
combination therapies — now considered the most effective treatment
against the parasitic disease — was unveiled today in Norway.
The other study showed how using a
combination of
drugs at increased potency could prove an effective therapy
against glioblastoma by inhibiting the PI3K and MAPK cellular pathways.
NEW ORLEANS, LOUISIANA — It's far from the ideal therapy, but scientists say a new
combination of two old
drugs is an important step forward in the fight
against sleeping sickness, a long - neglected tropical disease.
«We used clinical microbiology tests to determine whether the molecules had promising activity
against Cryptococcus both alone and in
combination with other antifungal
drugs such as fluconazole.
«Since doxorubicin is one of the cheapest
drugs that is effective
against many types of cancer but rarely used in colon cancer, the
combination therapy could be highly effective in combating colon cancer while drastically lowering risk of cardiotoxic side effects.»
Researchers used the mice to show that pemetrexed and gemcitabine worked
against human group 3 tumors and that the
drugs could be used in
combination with existing chemotherapy agents to boost treatment effectiveness without undue risk.
He adds, «This study was actually a pilot project for a much larger effort within the Center for Molecular Therapeutics to map responses
against drug combinations across hundreds of cancer cell lines, not just melanoma, and look for novel
combinations that will benefit subsets of patients regardless of the particular type of tumor they have.
The studies support the concept of using natural exposure in
combination with malaria - fighting
drugs to help people build up protection
against disease, says malaria vaccine researcher Robert Sauerwein of the Radboud University Nijmegen Medical Center in the Netherlands.
Drs. Baughn and Minato hope that the understanding of mechanisms for synergy will lead them and others to more potent
drug combinations that can be deployed in the fight
against pathogenic microbes as
drug resistance becomes increasingly commonplace.
A team of Massachusetts General Hospital (MGH) investigators has discovered a new
combination of
drugs that may be effective
against one of the deadliest cancers, malignant melanoma.
More than 5,775 potential
drug combinations, as well as each single
drug, were screened
against each cell line, looking for effects on the number and viability of tumor cells.
That automation is a clear selling point for Matthew De Silva, whose company, Notable Labs, is trying to devise personalized treatments for brain cancer by testing
combinations of thousands of Food and
Drug Administration — approved
drugs against each individual patient's tumor cells.
According to Dr William S Yancy Jr (Duke University, Durham, NC), lead author on the study, this is the first time the low - carb diet has been pitted
against a diet
drug in
combination with a different diet.»
The
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The 2 generics have most recently been successful on motions dismissing their cases as they relate to a patent to one
drug that was deemed not eligible for inclusion on the patent register
against a
combination.
A promising direction for future prevention studies would be to test a
combination of the elementary grade interventions used here with middle school curricula that seek to promote norms
against health - risk behaviors such as
drug use and to enhance life skills to resist health - compromising social influences.3, 6,7,31