Sentences with phrase «drug combinations work»

Why the drug combination works in resistant CML Why such a combination of the two inhibitor types works in an animal model has now been explained by Prof. Stephan Grzesiek's team at the Biozentrum of the University of Basel and Dr. Wolfgang Jahnke from Novartis, by a structural analysis using nuclear magnetic resonance spectroscopy (NMR).

That drug combination worked for about a year before Rose's cancer became resistant in April 2014.

Not exact matches

Another example, he said, is the National Cancer Institute's drug formulary launched in 2017 that helps researchers quickly access commercial cancer drugs under development, to test promising drug combinations in clinical trials, an effort made possible after difficult issues of intellectual property, access and licensing were worked out.

The research team currently is working to identify new biomarkers that will allow them to develop a better understanding of how drug resistance develops, and how to best design effective combinations of medications that may improve patient responses.

Erbitux works for 15 to 20 percent of patients when used in combination with another drug, but it can attack the skin.

Cancer researchers have long observed the value of treating patients with combinations of anti-cancer drugs that work better than single drug treatments.

Roche has four biologic cancer immunotherapy molecules in clinical trials that could work in powerful combinations with each other or with current drugs, says William Pao, global head of oncology discovery in Basel.

That means a future drug may require either a cocktail of HA head group binding proteins or work in combination with stem - binding versions.

The biologists studied how effectively every single possible combination of drugs worked to kill the bacteria.

The latest findings build on previous work by Dr. Habib's lab showing that the same combination of drugs was successful in a mouse model of glioblastoma, a deadly type of brain cancer.

Maria Zajac - Kaye, Ph.D., an associate professor in the College of Medicine's department of anatomy and cell biology, and Rony François, an M.D. / Ph.D. student who works with her, found a new drug combination that inhibits one form of pancreatic cancer tumor and kills its cells.

Their latest work, which is published online and appears in the current print edition of the Journal of the Royal Society Interface, extends their understanding of that phenomenon and identifies two combinations of drugs that are unexpectedly successful in reducing the growth of E. coli bacteria.

«I doubt a single drug will ever work in this cancer, so it is a matter of finding which drugs in combination are going to be most effective,» says Dr. Smallridge.

A combination of techniques — from computation to medicinal chemistry — helps scientists pick better drug targets, often because of gaining a better understanding of how diseases work

Alternatively, a combination of treatments might work, Hunt says, possibly using a probiotic to modulate the gut microbiome, and an anti-inflammatory drug to dampen the immune response and problems associated with immune activation.

University of Calgary researchers including Luchman, Weiss and Dr. Greg Cairncross — director of SACRI, and leader of the Terry Fox Research Institute (TFRI) «Therapeutic Targeting of Glioblastoma research program at the university — are now working with cancer researchers Dr. Warren Mason (Princess Margaret Cancer Centre in Toronto) and Dr. Lesley Seymour (Director of the NCIC Clinical Trials Group's Investigational New Drug Program), and drug manufacturer AstraZeneca, to plan a clinical trial testing a similar, but newer, drug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with glioblastDrug Program), and drug manufacturer AstraZeneca, to plan a clinical trial testing a similar, but newer, drug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with glioblastdrug manufacturer AstraZeneca, to plan a clinical trial testing a similar, but newer, drug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with glioblastdrug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with glioblastoma.

The interactions between these drugs could be additive, meaning the drugs work well together; synergistic, meaning the drugs enhance each other's effects; or antagonistic, which occurs when the combination of drugs seems to reduce overall effectiveness.

The study, based on work done by Doris Germain of Mt. Sinai Hospital, found that the combination of the drugs bortezomib and fulvestrant — versus fulvestrant alone — doubled the rate of survival at 12 months and reduced the chance of cancer progression overall.

But that day will come, Steve Kay asserts, once researchers figure out the correct combination of drugs that work simultaneously on multiple triggers of eating and metabolism, just as hypertension is now routinely treated with two - or three - drug combinations.

Taken separately or in combination, these drugs work somewhat in some patients and not in others.

That suggests there are super-rare «unicorn» patients whose unique glioblastoma and unique brain, with its characteristic immune system and genetics, might be vulnerable to a drug or a combination of drugs that, overall, doesn't work.

Welm thinks the drug might work well in combination with existing drug therapies to improve outcomes for patients, especially those whose disease is resistant to current treatments.

Treatment options include invasive surgeries and a combination of antiepileptic drugs that surprisingly don't work in more than 30 percent of patients.

To investigate why checkpoint inhibitors so often stop working, Velculescu; Valsamo Anagnostou, M.D., Ph.D., instructor of oncology at the Johns Hopkins University School of Medicine; Kellie N. Smith, Ph.D., a cancer immunology research associate at the Johns Hopkins University School of Medicine; and their colleagues at the Bloomberg ~ Kimmel Institute for Cancer Immunotherapy studied tumors of four patients with non-small cell lung cancer and one patient with head and neck cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or in combination with a second drug called ipilimumab, which uses an antibody called anti-CTLA4.

The drug, which works similarly to zidovudine (AZT) and ddI, is only for use in combination with zidovudine.

«Understanding how the drugs work gives us the opportunity to investigate new treatments, for example by using combination therapies, or altering the dosage and timing of treatment to prevent drug resistance from emerging,» Dr Glaser said.

Researchers used the mice to show that pemetrexed and gemcitabine worked against human group 3 tumors and that the drugs could be used in combination with existing chemotherapy agents to boost treatment effectiveness without undue risk.

Working with mouse prostate cancer cell lines in the laboratory, the investigators found that cells containing overexpressed TOP2A and EZH2 genes were highly sensitive to attack with a combination of two drugs.

«We were reassured that we did not find combinations of the most commonly used drugs that were absolutely forbidden,» she added, «one indication that drug safety systems used by physicians, nurses and pharmacists are working.»

Working closely with more than 200 data contributors, WWARN is able to use this powerful resource to perform pooled analyses that uncover new insights into the emergence and spread of malaria drug resistance, including evaluating the efficacy of antimalarial combination therapies (ACTs), and examining whether known molecular markers can predict clinical outcomes.

Combination antiretroviral therapy (cART) consists of a «cocktail» of several drugs that work together to reduce the amount of detectable virus (viral load) in the bloodstream.

Researchers are also finding ways to manipulate mAbs to make them even more powerful, and to craft them to work in combination with other drugs — for example, by delivering cancer - killing drugs directly to a tumor.

The U-M begins recruitment for the nation's first long - term study of diabetes drug combinations, which work best, have the fewest side effects and benefit overall health.

Best - in - class medicines begin with smart drug design to target multiple pathways and work in combination regimens.

The next step is when biologists and biotech stock market analysts start weighing in, predicting the usefulness (and investor appeal) of the drug combination, even when there are plenty of warning signs that it won't work.

We just keep trying different things until we hit upon a drug or drug combination that works.

Along with our collaborator in this program, Ludwig Cancer Research, we work to identify promising new drug combinations, partner with companies to gain access to these drugs, and then provide investment capital and clinical trial support to the academic investigators to help kick - start clinical development.

Working with animal models, researchers at Joslin Diabetes Center now have demonstrated the potential of giving a drug in combination with tPA that might improve stroke outcomes and increase the window of opportunity for the therapy.

The researchers are currently studying which drugs, or combination of drugs, work best to promote localized browning and increase overall metabolism.

These days, Galbraith is able to fully concentrate on her work, thanks to a combination of therapy (she sees her psychiatrist every three months, which helps her work through any emotional issues and self - defeating thoughts) and a prescription for Adderall, a stimulant that, along with Ritalin, is the most commonly prescribed drug for ADHD.

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It's important that you're aware of this connection because GlaxoSmithKline, the maker of the new prescription - strength fish oil medication, sold under the name Lovaza, has a new combination statin - fish oil drug in the works, which has reportedly already passed the required FDA tests.

«Lucy» is a combination of the title character's superhuman powers and a standard gangster melodrama, the former given life by a gorgeous series of psychedelic images and imaginative, fantasy scenes, while the latter exhibits groups of Taiwanese thugs with AK - 47's, a drug mob that kidnaps people and forces them to work as drug mules by implanting whole plastic bags of blue powder into their stomachs.

Medical researchers have found that treating some illnesses requires a drug «cocktail,» that is, no one medicine by itself works as well as the combination of several.

There are many prescription - strength NSAIDs (non-steroid anti-inflammatory drugs) that may be suitable or you may find a combination of Omega 3 fish oil and glucosamine works well for your dog.

The next research step is to further investigate propranolol and other beta blockers to see if they will work in combination with chemotherapy drugs, and then move to testing this new treatment approach in dogs with hemangiosarcoma.

A number of drugs are also available for pain relief and your vet can work with you to find the best combination for your dog.

Mixed breed or purebred, the best drug sniffing dogs have a combination of qualities that work together to make them good at what they do.

The same collection of drugs is depicted in Hirst's «Fact» painting «HIV AIDS, Drug Combination» (2006), which was also sold at the (RED) auction and which was exhibited together with «Where There's a Will, There's a Way» as part of «Requiem», the major 2009 exhibition of Hirst's work at the Pinchuk Art Centre, Kiev.