Research Paper Placenta - specific
drug delivery by trophoblast - targeted nanoparticles in mice Baozhen Zhang, Lunbo Tan, Yan Yu, Baobei Wang, Zhilong Chen, Jinyu Han, Mengxia Li, Jie Chen, Tianxia Xiao, Balamurali K Ambati, Lintao Cai, Qing Yang, Nihar R Nayak, Jian Zhang, Xiujun Fan Theranostics 2018; 8 (10): 2765 - 2781.
Investigation of Strategies for
Drug Delivery by Combination Targeting of Nanocarriers to Multiple Epitopes or Receptors.
Ultrasound improves
drug delivery by a mechanism known as transient cavitation.
Then they administered a carefully calculated sedative with a dart gun developed for large whale
drug delivery by Paxarms NZ in collaboration with Dr. Michael Moore, director of the Marine Mammal Center at WHOI and a marine mammal veterinarian.
Phase I funding — which allows up to $ 250,000 for an academic idea, such as decoding the genetic sequence of a protein or studying targeted
drug delivery by using magnetic nanoparticles — is available from federal funding and foundations.
Not exact matches
That has been my initial impression of a new
drug -
delivery system, called the Medici, which is made
by Intarcia Therapeutics.
Sales growth was led
by food safety, health information systems, and medical consumables;
drug delivery declined.
• Oculis, an Iceland - based developer of a solubilizing nanoparticle
drug delivery platform, has raised an undisclosed amount of Series A funding co-led
by Brunner Ventures and Silfuberg.
While some police departments have opted for a nasal spray version of the
drug, Orland Park officers will use injections, the same
delivery method used
by Orland Fire Protection District paramedics, he said.
I joke with my husband that I saved us a TON of money
by having a natural
delivery, no
drugs; breast feeding the babies, no formula, and letting the kids go naked most of the day while we are home - saves on diapers and laundry (we live in a tropical climate, so it is easy to do this!)
The Thinking Woman's Guide to a Better Birth
by Henci Goer Buy on Amazon - Buy on Book Depository Offers clear, concise information on alternative birthing methods * choosing a birth location *
drugs and
delivery * elective induction * professional labor support * and much more
Many women don't want to deliver in a hospital because they fear their choices — to avoid
drugs, to avoid surgery, to be surrounded
by their families, to be with the baby immediately after
delivery — will be taken away, said Carolyn L. Gegor, program director of the Nurse Midwifery / Women's Health Nurse Practitioner Program in the School of Nursing and Health Studies at Georgetown University Medical Center.
Haro Hartounian, a specialist in
drug -
delivery technologies at DepoTech in San Diego, predicts that microspheres will prove more potent than traditional booster shots and —
by eliminating that second visit to the doctor — could lower the cost.
When researchers examined the animals over the next several months, they found that this approach cured a much higher proportion of mice than
delivery of the
drug by other techniques.
While researchers have long worked with nanoparticles for
drug delivery, the findings put forth
by He and his team represent a crucial breakthrough in addressing multidrug resistance in cancer cells.
The new material, described online 25 April in Science
by synthetic chemist Andreas Lendlein of mnemoScience GmbH in Aachen, Germany, and biomedical engineer Robert Langer of the Massachusetts Institute of Technology, is composed of two polymers, each already used separately in clinical applications such as
drug delivery.
Siranda Torvaldsen of the University of Sydney, Australia, found that 416 women given the opioid
drug fentanyl
by epidural injection during
delivery were twice as likely to have stopped breastfeeding their baby
by the age of six months compared with 312 women who didn't receive epidural fentanyl (International Breastfeeding Journal, DOI: 10.1186 / 1746 -4358-1-24).
The recent growth is driven, experts say,
by aging populations and increased life expectancy in the developed world; combination products that couple a medical device with a
drug, the device usually acting as a
drug -
delivery vehicle; miniaturization (via nanotechnology), making medical devices less invasive; and the use of molecular diagnostics to customize therapeutic regimens and to assess individual disease risk.
By controlling the timing of the interaction, researchers could pinpoint
delivery of the
drug to a precise location, thus preventing side common side effects of chemotherapy, such as hair loss or cardiac toxicity.
Researchers at McGill University have developed a new, low - cost method to build DNA nanotubes block
by block — a breakthrough that could help pave the way for scaffolds made from DNA strands to be used in applications such as optical and electronic devices or smart
drug -
delivery systems.
Microfluidics engineers grapple with it when they try to pack as many
drug -
delivery bubbles as they need into a tiny capillary tube, and manufacturers confront it when they try to cut shipping costs
by packing as many bouncy balls into as small a package as possible.
iRGD is therefore potentially useful to optimize the
delivery of cancer
drugs by the nanoparticle to the tumor.
By 2010, the nation will be able to host 15 world - class biomedical sciences companies and will become the region's hub for biomedical sciences activities, including
drug discovery and development, clinical research, and health care
delivery.
Johns Hopkins biomedical engineers have teamed up with clinicians to create a new
drug -
delivery strategy for a type of central vision loss caused
by blood vessel growth at the back of the eye, where such growth should not occur.
The research was led
by Professor Cameron Alexander, Head of the Division of
Drug Delivery and Tissue Engineering and EPSRC Leadership Fellow in the University's School of Pharmacy, building on work
by PhD student Peter Magennis.
More importantly,
by varying the ratio of these two materials and modifying the capsule design, targeted
drug delivery either to the stomach, the small intestine or the colon can be achieved.
And a few different techniques have since emerged to improve
drug delivery, and,
by extension, safety — such as Alnylam's approach of binding the RNAi therapeutic to a lipid nanoparticle, or fat, to help it settle in the liver.
Research led
by Rein Ulijn, Director of the CUNY Advanced Science Research Center (ASRC)'s Nanoscience Initiative and Professor of Chemistry at Hunter College, has paved the way for the development of dynamically - evolving polymers that form spontaneously
by adapting to their environment, which may lead to a number of product possibilities including
drug delivery, food science and cosmetics, the results of which were published today in Nature Nanotechnology.
By controlling the pore structure of the material the amorphous phase stabilisation exerted on poorly soluble
drug compounds can be tuned and the
drug delivery rate can be tailored.
In theory, superparamagnetic particles could be ideal for
drug delivery, as they can be directed to a tumor simply
by using a magnetic field.
This method of making larger superparamagnetic crystals paves the way for the development of superparamagnetic bulk materials that can be reliably controlled
by moderate external magnetic forces, revolutionizing
drug delivery to tumors and other sites in the body that need to be targeted precisely.
The research being carried out
by Berzins, Bunge and Goodyer is extremely relevant to
drug delivery via skin patches and Professor Hadgraft has an ongoing collaboration with them.
They hope to be able to model
drug delivery through skin using the computer simulations developed
by the team.
«Our vaccine was made possible
by combining a wide range of biomedical expertise that thrives in Boston and Cambridge,» said Mooney, who specializes in the design of biomaterials for tissue engineering and
drug delivery.
A new study shows that a 70 - year - old malaria
drug can block immune cells in the liver so nanoparticles can arrive at their intended tumor site, overcoming a significant hurdle of targeted
drug delivery, according to a team of researchers led
by Houston Methodist.
Prior studies suggested that nanoparticle
drug delivery might improve the therapeutic response to anticancer
drugs and allow the simultaneous monitoring of
drug uptake
by tumors.
An article
by Dr. Aihui Ma - Ham, Dr. Zhiwen Tang, Ms. Hong Wu, Dr. Jun Wang and Dr. Yuehe Lin in Small reviewed current developments in one area of promise for nanomaterials: protein - based nanomedicine platforms for
drug delivery.
Shahab explaines the study's findings would pave the way for designing more - efficient
drug delivery capsules in the future, especially those that can be activated
by focused ultrasound waves.
The product combines pancreatic progenitor cells called PEC - 01, produced
by a directed differentiation process, encapsulated with a semi-permeable device called the Encaptra ®
Drug Delivery System, both are proprietary technologies.
Our therapeutic siRNA molecules are combined with
delivery systems, which markedly enhance the efficiency and specificity of our siRNA
drugs by directing them to the right cell type in the body and sparing healthy tissues.
Using nanoparticles, Yale researchers have developed a
drug -
delivery system that could reduce organ transplant complications
by hiding the donated tissue from the recipient's immune system....
The possibility of using novel
drug delivery systems for known and new antibiotic
drugs opens the way to an innovative management of infections caused
by drug resistant bacteria, which are otherwise difficult to treat.
The targeted
drug delivery appears to be a very promising strategy for controlling the biodistribution of the cytotoxic agent only on malignant tissues
by linking it to tumor - targeting moiety.
Shandiz Tehrani, MD, PhD Oregon Health & Science University, Portland, OR Funded
by The Alcon Foundation Project: Local
Drug Delivery to the Optic Nerve Head as a Novel Treatment in Experimental Glaucoma
A new, nanoparticle - based
drug delivery system being developed
by health physics professor Steen Madsen offers new treatment for glioblastoma.
-LSB-...] systems for
drug delivery (for example) are not the only means
by which nanotechnology is contributing to the advance of medicine.
Some of their goals include the unravelling of disease mechanisms
by using nanomaterials to track cellular components and probe the chemical niche of the cells, the transformation of adult human cells into induced pluripotent stem cells and the
delivery of
drugs directly to immune and cancer cells.
The
delivery of
drugs transdermally (through the skin) is a practice used in medicine to avoid the risk or inconvenience of intravenous therapy, to lower loss of absorption as a
drug passes through the gastrointestinal tract, to lower metabolism of the
drug by the liver, and to provide a more targeted application (such as a topical non-steroidal anti-inflammatory
drug delivery via patch vs. swallowing a pill).
When tricked into making the
delivery, Lucy finds the Korean mob headed
by Jang to be a group of ruthless killers who implanted a bag of an experimental recreation blue crystal
drugs in her intestines for her to be a
drug mule.
Conceived as a loose riff on star Channing Tatum's time as a male stripper, it has a solid run as a cheerful smut
delivery mechanism before hanging up its thong to become a rote «80s melodrama about good kids corrupted
by bad
drugs.