Sentences with phrase «drug design by»

«These new findings will have important implications for drug design by clearly defining exactly how these signals become integrated, so we will be able to predict how changes in a drug's design could affect signaling.»

The specific drugs designed by WAVE have been tested in cells in a petri dish, where they successfully lowered the mutant protein whilst leaving the normal version relatively untouched.

Not exact matches

In particular, the complaint alleges that throughout the Class Period, defendants made materially false and / or misleading statements and / or failed to disclose that (1) the trials for GED - 0301 suffered from fatal design defects, such that GED - 0301 had failed to demonstrate meaningful clinical efficacy; (2) the growth of Otezla sales had dramatically slowed during Celgene's third fiscal quarter of 2017; and (3) the clinical and nonclinical pharmacology data in Celgene's new drug application («NDA») for Ozanimod were insufficient to permit a complete review by the FDA, which resulted in the FDA issuing a refusal to file letter to Celgene regarding the NDA.

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

What Boger wants is to create a better way to develop drugs: through a process called structure - based design in which scientists build up a new drug, atom by atom, after determining the type of molecule that might interrupt the disease process.

Late last week, the Food and Drug Administration gave its stamp of approval to the marketing of the world's first device designed to help diagnose ADHD — a disorder that plagues some 6.4 million children — by scanning a child's brain waves.

We need to design clinical trials and outcomes in a way that captures the downsides of aging in a quantitative way» that allows targets for drug approvals by the FDA.

That cash doesn't include the money PhRMA's spending on the ongoing «Go Boldly» campaign, a series of TV, print and radio ads designed to polish the drug industry's image by reminding the public that drug companies do world - class research that brings disease cures to market to save lives.

The conscience you try and drown out with alcohol, drugs, and sarcastic comments... Well it turns out that conscience of yours was designed by God to wake you up out of your foolishness.

In June 2016, the Food and Drug Administration (FDA) announced draft voluntary sodium reduction targets, which were partly informed by the design of the National Salt Reduction Initiative.

This program is designed to target and shut down known drug markets by establishing programs through which police can collaborate with both prosecutors and the general public.

Officers in all but five police departments in Erie County carry naloxone, known by the brand name Narcan, a rescue nasal spray designed to revive users who overdose on opioid drugs.

Drugs designed to cut the risk of heart disease are being talked down amid a worrying lack of use by people who could benefit from them, says Anthony Warner

One of those licenses went to Michael Hackett, a UNC doctoral student who got an idea 2 years ago for a potential commercial drug: to trick tumors into absorbing chemotherapy drugs by designing a molecular Trojan horse.

We currently do not know how these genetic risk factors affect the chemistry of the brain and cause specific symptoms, so it is not yet possible for scientists to design drugs to relieve symptoms shown by people with a particular genetic variant.

Chemotherapy drugs designed to kill tumors may actually encourage ovarian cancer by stimulating the growth of cells that give rise to the malignancy, a new study finds.

Chemotherapy drugs are often designed to kill off malignant cells by damaging their DNA until they transition to a programmed death mode called apoptosis.

Published in the journal Molecular Cancer Therapeutics, the study also found that use of a second inhibitor might improve the effectiveness of these drugs by possibly preventing resistance, and it recommends that clinical trials should be designed to include a second inhibitor.

It also suggests the possibility of designing better sleeping pills by finding compounds that mimic adenosine's effects, says McCarley, who points out that current drugs do not target the adenosine receptors.

People working in biomanufacturing need to be prepared for inspections by the US Food and Drug Administration and the European Medical Evaluation Agency designed to ensure that mass - produced proteins are of the same quality as those used in clinical trials.

Since many human diseases can be explained by perturbations of molecular interactions within cells, interactomes will drastically change how we think about human health, and how we set about designing drugs and preventive measures to counter illness.

Most drugs are designed to interfere with a specific disease pathway by elbowing their way into important spots inside the cell.

«This will require discussions about alternative approaches to the design and conduct of clinical trials as well as to how interventions are approved by the Food and Drug Administration.»

A statin drug commonly used to lower cholesterol is not effective in reducing the number and severity of flare ups from chronic obstructive pulmonary disease (COPD), according to the results of a large multicenter clinical trial designed and directed by Gerard J. Criner, MD, Director of Pulmonary and Critical Care Medicine at Temple University Hospital in Philadelphia, PA..

The determination of each efficacy level was also based on the rigor and quantity of published studies on the drug class: to be in Level A, for example, a class of drugs must have been supported by at least two «Class I» studies — well - designed, double - blind, randomized, placebo - controlled clinical trials.

The researchers targeted mTOR with an experimental drug based on a prototype first designed by Shokat, a chemist and an expert in designing molecules to target this type of protein, called a kinase.

Other experimental options include: — AVI - 7537, a drug designed to block viral protein from being made, has shown human tolerability in early studies and could have 100 courses available by early 2015.

«Imaging of the joint could help evaluate the mechanism of a drug's therapeutic effect, and if a process turns out to be mediated by more than one chemoattractant, understanding the mechanism would allow the rational design of combination therapies to completely shut down critical steps in the process.»

In medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered and / or designed.

He's also likely to spur the FDA to follow the course laid out by agency cancer czar Richard Pazdur in speeding new approvals, possibly setting up a special unit aimed at orphan drugs to hasten OKs with smaller, better designed clinical trials.

«Some psychotic disorders may be induced by drugs designed to combat effects of epilepsy.»

Downing and the team evaluated the strength of clinical trial evidence supporting FDA approval decisions for new drugs by characterizing key features of efficacy trials, such as trial size, design duration, and end points.

In one set of tests designed to quantify how much the rats desired each drug, they could get another infusion only by making ever - greater numbers of lever presses.

A molecule in cells that shuts down the expression of genes might be a promising target for new drugs designed to treat the most frequent and lethal form of brain cancer, according to a new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

Designed by researchers at Sangamo Biosciences, the drug uses a natural protein that turns on the patient's own gene for helping nerve growth.

Scientists say that the new design may eliminate the problems with the failed 2002 vaccine (manufactured by Elan Corporation, an Ireland - based drug company).

«We hope this technology will in future enable researchers to design personalised diets or drugs that can efficiently target problem areas in the gut, to help the millions of people worldwide that are affected by digestive disorders and diseases.»

The experiment was designed by pharmaceutical firm Novartis, which will use the data to design drugs to combat the disease.

Led by two groups — the Coalition for Mercury - free Drugs and SafeMinds — they have brought the thiomersal «debate» into negotiations designed to address environmental problems.

«Given that marijuana is the most commonly used illicit drug by high school students in the U.S., having a better understanding of how marijuana use affects future SC use and vice versa is essential for designing effective prevention and intervention programs.»

By performing experiments in petri dishes and with mice, they found that panobinostat, a drug designed to change the way cells regulate genes, may be effective at inhibiting DIPG growth and extending survival rates.

Antisense drugs are designed to enter cells and eliminate viruses by preventing their replication, Bavari explained.

We refer to these as «alerts»: they can be used by drug design experts to try to avoid certain interactions and / or structures in order to develop safer drugs,» says Aloy.

In drug design, for example, the function of a protein is determined by sequence comparison and 3D modelling programs.

«The hydrogel is designed so that drug release is triggered by the activity of specific, arthritis - related enzymes that are increased during flares.

It was the first drug designed to inhibit new vessel growth (angiogenesis), and was approved by the FDA in 2004 for treating colorectal cancers — which typically boost angiogenesis to keep themselves well supplied with oxygen and nutrients.

These are the first ever drugs specifically designed to prevent the crippling headaches before they start, and they could be approved by the U.S. Food and Drug Administration next year.

A team of researchers led by biophysicists at the University of Washington have come one step closer to designing tailor - made drug molecules that are more precise and carry fewer side effects than most existing therapeutic compounds.

«Now, because we know the resistance mechanism, we can design elements to minimize the emergence of resistance as these promising new drug candidates are developed,» said Ben Shen, a TSRI professor who led the study, which was published February 20, 2014 online ahead of print by the Cell Press journal Chemistry & Biology.

While the United States focuses on figuring out how to keep drugs and other chemicals out of the nation's waterways, the European Union's approach could be called «benign by design.»