Sentences with phrase «drug design strategies»

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These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

The evolutionary principles of natural selection, variation, and recombination are the basis for genetic algorithms, an engineering technique that has many practical applications, including aerospace engineering, architecture, astrophysics, data mining, drug discovery and design, electrical engineering, finance, geophysics, materials engineering, military strategy, pattern recognition, robotics, scheduling, and systems engineering.

Mr Straw today committed the government to a new strategy designed to get prisoners off drugs, as well as helping offenders into work.

«We could apply the strategy used in this study to quickly identify and design small molecule drugs for other RNA - associated diseases,» explained study first author Sai Velagapudi, a research associate in the Disney lab.

«Understanding how drug resistance develops can help in the design of new agents or strategies to overcome resistance,» says principal investigator Sameek Roychowdhury, MD, PhD, assistant professor of medicine and of pharmacology in the Division of Medical Oncology at the OSUCCC — James.

But researchers have had only a blurry picture of gp120's structure — not enough to design well - targeted drugs or mount an effective vaccine strategy.

«If we can understand how the antidepressant causes adverse metabolic outcomes in the offspring than we can design therapeutic strategies to prevent the damage while allowing women who require these drugs to be treated but reduce the potential harm to the offspring.»

• Penalties of up to $ 10 million may be imposed for violations of the new REMS (risk evaluation and mitigation strategy) provisions, designed to manage a known or potential serious risk associated with a drug or biological product.

A close look at the inner workings of microbes in this era of escalating antibiotic resistance is offering new strategies for designing drugs

Gerry Potter and Ray McCague of the Institute of Cancer Research in Surrey based their design strategy on tamoxifen, a drug widely used for treating breast cancer.

«They also provide a promising strategy for identifying small molecule drugs designed to treat Alzheimer's disease and other neurological disorders.»

Professor Michael Lisanti, who designed the study, explained: «We now know that a proportion of cancer cells escape chemotherapy and develop drug resistance; we established this new strategy to find out how they do it.

«Computational strategies overcome obstacles in peptide therapeutics development: New approaches offer advantages in attempting to design midsize drug compounds.»

«Our new structure of the serotonin receptor in the resting state has the potential to serve as a structural blueprint to drive targeted drug design and better therapeutic strategies.»

An emerging strategy in early drug discovery entails using fragments, i.e. molecules smaller than conventional drug candidates, as starting points for design of novel therapeutic compounds.

With the goal of creating a vault capable of encapsulating therapeutic compounds for drug delivery, UCLA doctoral student Daniel Buhler designed a strategy to package another nanoparticle, known as a nanodisk (ND), into the vault's inner cavity, or lumen.

In its May 13, 2014 Statement, the Bureau stated that «product life - cycle management strategies in the pharmaceutical sector are not inherently anti-competitive... However, life - cycle management strategies that are designed to impede competition from generic drug companies, such as product switching strategies, may cause significant harm to competition.»

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Thermafreeze (Red Bank, NJ) 09/2009 — 11/2010 National Sales Manager • Designed and implemented a comprehensive sales and marketing strategy for a retail manufacturer of alternative ice products • Successfully led the conversion from a commercial manufacturer to a retail manufacturer • Established a national tier 1 independent broker network resulting in significantly enhanced corporate reach and revenues • Trained brokers and salespeople in sales and marketing best practices, presentation techniques, and product information • Organized national tradeshows to introduce ThermaFreeze to supermarkets, mass merchandisers, and the drug store industry • Devised and successfully executed strategies for product image, branding, packaging, retail displays, and shipping

BreakThrough was designed to help families of people who use ice, by providing information strategies to help manage the challenging behaviours associated with drug use.

The mission of Stand Strong is to actively develop and implement various prevention strategies designed to reduce and prevent the use of alcohol and drugs by the youth within the communities of School District 125 (Adlai E. Stevenson High School).