The term
"drug discovery efforts" refers to the process of identifying and developing new drugs or medications that can help treat various diseases, conditions, or disorders.
Full definition
Attrition of novel drug candidates due to cardiovascular liabilities (including proarrhythmic risk due to delayed ventricular repolarization and Torsades - de-Pointes arrhythmia) remains a hurdle
for drug discovery efforts, a hurdle which may be mitigated by the use of human induced pluripotent stem - cell derived (hiPSC)- cardiomyocytes.
Our research aims at identifying the principles of neuronal interactions with signals from the cellular microenvironment and uncovering disease - relevant targets that can be harnessed to
drive drug discovery efforts in neurological and age - related neurodegenerative diseases.
Chemogenomics is a new concept where drug design and screening is conducted at the genome level for
selective drug discovery effort against one target among a large family of related proteins / receptors.
Diseases of the developing world, such as secretory diarrhea, have little commercial interest for the pharmaceutical industry and represent a gap that is productively filled by
academic drug discovery efforts.
The SDDC consists of the top Structural Genomics groups in North America, collaborating to support structure -
guided drug discovery efforts for high - value targets.
Brent Stockwell, Ph.D., Assistant Professor in the Department of Biological Sciences and the Department of Chemistry at Columbia University
leads drug discovery efforts.
Since 1997, it has been our mission to provide ubiquitin proteasome pathway (UPP) researchers with innovative tools that facilitate and
accelerate drug discovery efforts.
There are, however, several challenges to generate soluble and stable complexes, and this is one of the many reasons why not many X-ray structures are available, especially at resolutions suitable to
drive drug discovery efforts.
«These ligases are being actively developed in
drug discovery efforts,» Hogenesch noted.
A global consortium of HD researchers has just published a landmark study of genetic differences between people that might explain some of that variability, producing some tantalizing new targets for
drug discovery efforts.
It can be used to study a particular chemical compound of interest in great depth, or in a broader screen at the starting point of
a drug discovery effort.