Sentences with phrase «drug efflux»

The resulting phenotype is highly motile and possesses stem - cell - like properties, a high degree of resistance to treatments, and an increased rate of drug efflux.

Among other things, we have identified one mechanism of multi-drug resistance (MDR) involving P - glycoprotein (Pgp) which functions as a drug efflux pump of broad specificity.

Heterogeneity in a bacterial population that arises through a mechanism of biased partitioning of drug efflux pumps, as we identified in our study, could be a stepping - stone on the path of bacterial populations towards antibiotic resistance.»

Not exact matches

To address this challenge, our research group is using nanoparticles not only to deliver more chemotherapy drugs to the target site within cancer cells, but also to compromise the function of the efflux pumps and thereby significantly improve safety and efficacy of cancer therapy.»

Studies have revealed that the drug also inhibits bacterial efflux pumps that permit bacteria to survive within cells.

If a pathogenic strain of bacteria acquires a gene encoding one of these efflux pumps, then it will suddenly become resistant to multiple antibacterial drugs.

Sello and a team of researchers from Brown have come up with a new strategy that may help sneak drugs past the efflux guards.

«There are efflux pumps that can export multiple drugs that have different structures and mechanisms of action.

New supercomputer simulations have revealed the role of transport proteins called efflux pumps in creating drug - resistance in bacteria, research that could lead to improving the drugs» effectiveness against life - threatening diseases and restoring the efficacy of defunct antibiotics.

Since an efflux pump could compromise the potency of even a newly developed antibacterial drug, we need to think about ways to circumvent these efflux pumps.»

The TB bacteria use efflux pumps as a strategy to remove drugs and other threats from the cell before they can work against the bacteria.

For example, up - regulated influx transporters (OCT3 and OCTN1) localized at the apical membranes of Sertoli cells could mediate the transport of the drug compound 9 from the lumen into the basolateral compartment of Sertoli cells, where the up - regulated efflux transporters (ABCB1 / p - glycoprotein, ABCB8, ABCB9, ABCC5, and ABCC10) could then transport the drug out of Sertoli cells against a concentration gradient, resulting in enhanced efficiency of recovery upon cessation of treatment.

Indeed, we found that long - term drug treatments were associated with increased expression of several ABC efflux transporters and influx transporters.

A, The expression of several ABC efflux transporters, including Abcb1a, Abcb9, Abcc5, and Abcc10, were significantly up - regulated in testes after long - term drug treatment as compared with the control.

Second, our current study suggests that after the long - term drug administration in mice, the more rapid recovery may also involve the interplay of ABC efflux transporters and SLC influx transporters in the testes.

P - glycoprotein mediated efflux limits substrate and drug uptake in a preclinical brain metastases of breast cancer model.

Efflux pumps are surface proteins that prevent antimicrobial drugs from getting a foothold in a bacterial cell by identifying and pumping them out of the cell.

Our data suggest that changes in the expression of genes associated with drug resistance and cancer cell «stemness», induced by treatment with MIA - 602, lead to a significant reduction in the efflux capacity of drug resistant cells.

This results in the accumulation of the cytotoxic drug in cells with disabled efflux mechanisms and reduces resistance.

: This study evaluated the effects of an antagonistic analog of growth hormone - releasing hormone, MIA - 602, on tumor growth, response to doxorubicin, expression of drug resistance genes, and efflux pump function in human triple negative breast cancers.

Introduction: This study evaluated the effects of an antagonistic analog of growth hormone - releasing hormone, MIA - 602, on tumor growth, response to doxorubicin, expression of drug resistance genes, and efflux pump function in human triple negative breast cancers.

We examined the effects of treatment on tumor growth, drug resistance, GHRH - R levels, expression of MDR1 and Nanog, and efflux pump activity.

decreases drug resistance in Lyme by blocking efflux pumps that remove antibiotics from germs,