The study used a well - known line of pancreatic cancer cells (AsPC - 1) in the laboratory and assessed how well this grew when treated with either the chemotherapy
drug gemcitabine or different levels of commercially available chokeberry extract alone, and when treated with a combination of gemcitabine and chokeberry extract.
By contrast, a signal of tumor activity increased sixty-fold in mice treated with the widely used chemotherapy
drug gemcitabine.
The research team evaluated the combination of the biologic therapy brentuximab vedotin (Adcetris), a monoclonal antibody - drug conjugate, with the chemotherapy
drug gemcitabine (Gemzar) in 42 pediatric and young - adult patients with Hodgkin lymphoma, the most common cancer in young people ages 15 to 29.
Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic
drug gemcitabine.
Certain types of bacteria make an enzyme that inactivates
the drug gemcitabine, researchers report in the Sept. 15 Science.
Not exact matches
This time, she was given different chemotherapy — docetaxel and
gemcitabine — as it was assumed that her cancer had grown resistant to the previous
drugs, and, after several weeks, the tumours had shrunk right down.
In a recent study, working with a team of researchers, Danino demonstrated that bacteria in pancreatic tumors degrade a chemotherapy
drug —
Gemcitabine — most commonly used to treat patients who have pancreatic cancer.
The researchers isolated bacteria from the tumors of pancreatic cancer patients and tested how they affect the sensitivity of pancreatic cancer cells to
gemcitabine, a chemotherapy
drug.
The current standard of care for advanced pancreatic cancer — a combination of nab - paclitaxel and
gemcitabine — was developed by TGen and the HonorHealth Research Institute, and approved by the U.S. Food and
Drug Administration in 2013.
They were able to show that treatment of the cells with three
drugs, called obatoclax, saliphenylhalamide and
gemcitabine, prevented synthesis of viral building blocks and production of new viruses at concentrations that are not toxic to cells.
Another common and newer
drug used to treat pancreatic cancer is
gemcitabine, which also mimics one of the building blocks of DNA and interferes with the ability of cancer cells to reproduce.
Researchers used the mice to show that pemetrexed and
gemcitabine worked against human group 3 tumors and that the
drugs could be used in combination with existing chemotherapy agents to boost treatment effectiveness without undue risk.
When pemetrexed and
gemcitabine were combined with two chemotherapy
drugs currently used to treat pediatric medulloblastoma, the mice lived even longer.
Researchers demonstrated that the
drugs pemetrexed and
gemcitabine killed cells from mouse and human brain tumors, called group 3 medulloblastoma, growing in the laboratory.
One,
gemcitabine, is an FDA - approved chemotherapy
drug that works by slowing or stopping the growth of tumors.
The targeted anti-cancer
drug erlotinib (Tarceva ®) has also demonstrated a small improvement in advanced pancreatic cancer survival when used in combination with
gemcitabine.
Each patient will receive
gemcitabine and nab - paclitaxel, two chemotherapy
drugs that are standard of care.