Sentences with phrase «drug inhibits»

100 uM dideoxystreptamine - based drug inhibits colon cancer cell migration in the high - throughput Platypus fluorescent assay

The drug inhibits the Aurora Kinase A signaling pathway, causing cells to stop dividing.

Its new two - pronged drug inhibits the enzyme and allows the antibiotic agent to destroy the bacteria.

Both drugs inhibit reuptake, or reabsorption, of these neurotransmitters by neurons, thus prolonging their action.

The natural human antimicrobial peptide LL37 and the colistin drug each inhibited growth of about 50 percent of the clinical isolates, indicating a high level of bacterial resistance to these drugs.

A 2006 study in the Journal of the American Medical Association reported that people taking long - term, high - dose proton pump inhibitors are 2.65 times as likely as controls to experience hip fractures, possibly because the drugs inhibit calcium absorption.

These drugs inhibit the reabsorption of serotonin, making it available longer for transmitting signals between neurons.

Therefore, the research shows that these mutations affecting the signalling route which depends on the ATM protein, as well as the drugs inhibiting the function of this signalling route such as some anti-tumour drugs, could produce infertility problems in humans.

In animal and cell culture studies, the drug inhibited growth both in estrogen - dependent breast cancer cells and in cells that had developed resistance to the anti-estrogen tamoxifen and / or to the aromatase inhibitors, two of the most widely used types of drugs to prevent and treat estrogen - dependent breast cancer.

Currently available antiviral drugs inhibit influenza virus replication, but they are not typically effective when given to patients as little as 2 days after infection.

As these compounds are already approved for clinical trails in pediatric brain tumors, these findings suggest that drugs inhibiting MEK activity could offer a new therapy option for children with these devastating tumors.

In addition, the drugs inhibit a disease in rats called experimental autoimmune ence - phalomyelitis.

Both drugs inhibit the synthesis of these blocks, called nucleotides, and thereby induce senescence and stop cancer in its tracks.

«New treatment targets cancers with particular genetic signature: Mutations in gene SETD2 make cancer cells vulnerable to drug inhibiting the protein WEE1.»

Aspirin, ibuprofen, and other nonsteroidal anti-inflammatory drugs inhibit both COX - 1 and COX - 2.

«But since these drugs inhibit all prostanoids, each may contribute differently towards the immunity against influenza virus,» says Francois Coulombe, a McGill Ph.D. student and the study's first author.

In experiments, one such drug inhibited these GABA neurons, thus allowing for an increase in activity among the glutamate neurons, and, as a result, producing an antidepressant effect in the mice.

«Scientists have not looked carefully at how drugs used to prevent organ rejection can have a detrimental effect on bone, but our study would suggest that if those drugs inhibit mTOR, they could disrupt bone formation.»

Some cancer drugs inhibit secreted growth factors but have been only partially effective at blocking angiogenesis (SN: 6/7/03, p. 358: Available to subscribers at Cancer Advance: Treatment combinations stall colorectal cancer).

A new study finds that more than 200 human - targeted, non-antibiotic drugs inhibit the growth of bacterial species that make up part of the human microbiome — Catherine Offord

It's well known that alcohol, nicotine and drugs inhibit the production of testosterone.

Autoimmune drugs inhibit inflammatory pathways or reduce the activity of immune cells.

Studies show that these drugs inhibit enzymes that are necessary for the synthesis of an important antioxidant called coenzyme Q10.

Not exact matches

LEEDERVILLE - BASED Pharmanet Group Ltd has announced positive results from research into its protein fragment drug, which inhibits reaction to UVB burns.

Illicit drugs that dump loads of dopamine (or strongly inhibit its reuptake, which is similar to dumping loads of dopamine) include cocaine and methamphetamines,» Dr. Emily Deans wrote at Psychology Today.

Its drug Niraparib kills cancer cells by inhibiting the production of proteins called PARPs, which help repair damaged DNA strands, thereby hastening the death of some types of cancer cells.

The move may inhibit competition by preventing generic drug - makers from obtaining access to samples, Stock said.

In addition, avoid any drugs that will cause drowsiness or inhibit your ability to wake up as necessary throughout the night.

Alcohol and drugs can make teenagers less inhibited.

You will be first given drugs that will inhibit the hormone that sustains the pregnancy after which you can go home.

Importing pharmaceuticals would inhibit the ability of pharmaceutical companies to make high profit margins on their drugs, which is needed to overcome the extremely high cost of gaining government approval to sell those drugs.

The researchers used a drug called clorgyline to inhibit the activity of the MAOA enzyme; the drug disrupted the signaling system that led to cancer cell invasion and proliferation.

To test whether this enzyme was to blame, they conducted a follow - up test with 18 of the over-65 participants, who took Losmapimod, a drug that inhibits the enzyme in order to reduce acute inflammation responses.

A single dose of the drug zoledronic acid was found to inhibit the bone loss that is common in HIV - infected patients and that is increased during the first two years of treatment with antiretroviral therapy (ART).

With this kind of review process, if 20 studies of the effectiveness of a truly ineffective drug are conducted, and one of them shows a significant effect with a p - value of 0.05 because of chance alone, investigators for the other 19 studies not showing any effect would presumably not be inhibited from writing up and submitting reports of these for publication out of fear that they'll be denied publication because of their nonsignificant results.

Denosumab, a fully human monoclonal antibody drug, binds specifically to RANK - ligand (RANKL) and inhibits osteoclast - induced bone resorption by preventing the binding of RANKL to RANK.

The PARP - inhibiting drug «doesn't have many side effects because it's a protein that's normally not required by the rest of the body,» Helleday says.

As a result, the drugs usually only inhibit the growth of precancerous cells, rather than killing them off.

The drug works by inhibiting an enzyme called low molecular weight protein tyrosine phosphatase (LMPTP), which seems to contribute to cells losing their sensitivity to insulin.

If the drugs also kill polyps in people, they could be taken less frequently than drugs that merely inhibit growth, limiting side effects.

If a plant treated with a potential drug exhibits low chlorophyll levels and fast stem growth, the compound might also inhibit glutamate overstimulation in the brain, she says.

GSK236671 is an investigational drug that inhibits a pathway often linked to cancer called PI3K.

This drug (vedolizumab) blocks a specific adhesion molecule on the surface of the T - cell and thereby inhibits immune cells from binding themselves to receptors present in the intestine, preventing the T - cells from penetrating the blood vessels in the intestinal tissue.

«When people have one copy of a gene not working, it's a little like taking a drug their entire lives that is inhibiting this gene.»

Current treatments for acute lymphoblastic leukemia (ALL), an aggressive form of blood cancer, include conventional chemotherapy drugs that inhibit DNA synthesis.

The research suggests that immune therapy for cancer might be more effective if combined with drugs that inhibit NF - kB.

Guo and his fellow researchers worked under the premise that inhibiting the FA pathway and combining this with DNA damaging chemotherapy drugs might be a promising strategy for cancer therapy.

It may be necessary for a drug to inhibit some, but not all, of the enzyme, enough to prevent plaque formation but also preserve normal signaling between nerve cells, Yan says.

The researchers then found that, while the drug continued to inhibit FGFR activity in the resistant cells, its inhibition of FGFR signaling had no appreciable effect on the cells» survival.

«Our findings underline the importance of RUNX2 in promoting metastasis and suggest that drugs that inhibit its function would prevent or treat prostate cancer metastasis,» notes Dr. Gelman.